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Nature 432, 157-158 (11 November 2004) | doi:10.1038/432157a; Published online 10 November 2004

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DNA repair:  Big engine finds small breaks

Anna Marie Pyle1

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When a break occurs in the DNA double helix, it must be dealt with rapidly. The structure of one of the cellular machines responsible is now revealed, offering insights into its impressive speed and flexibility.

A double-strand break in DNA is the cellular equivalent of a three-alarm fire. As any taxpaying citizen knows, most communities maintain an impressive collection of hardware for dealing with major emergencies.

  1. Anna Marie Pyle is in the Department of Molecular Biophysics and Biochemistry, and the Howard Hughes Medical Institute, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520, USA.
    e-mail: Email: anna.pyle@yale.edu

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