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News and Views
Nature 432, 157-158 (11 November 2004) | doi:10.1038/432157a; Published online 10 November 2004
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Head-Preclinical
- Syngene International
- Bangalore, Karnataka 560099 India
Tier II Canada Research Chair in Cellular Science and Human Health
- Concordia University
- Montreal, Quebec Canada
DNA repair: Big engine finds small breaks
Anna Marie Pyle1
Abstract
When a break occurs in the DNA double helix, it must be dealt with rapidly. The structure of one of the cellular machines responsible is now revealed, offering insights into its impressive speed and flexibility.
A double-strand break in DNA is the cellular equivalent of a three-alarm fire. As any taxpaying citizen knows, most communities maintain an impressive collection of hardware for dealing with major emergencies.
- Anna Marie Pyle is in the Department of Molecular Biophysics and Biochemistry, and the Howard Hughes Medical Institute, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520, USA.
e-mail: Email: anna.pyle@yale.edu
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