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Nature 432, 155-156 (11 November 2004) | doi:10.1038/432155a; Published online 10 November 2004

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Medicine:  A cholesterol connection in RNAi

John J. Rossi1

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RNA interference — RNAi for short — might provide a way to silence disease-associated genes, but problems of delivery have hampered progress. Those problems may have been solved, at least in animal studies.

On page 173 of this issue, Soutschek et al.1 describe a simple but effective method for the intravenous delivery of nucleic acids called short interfering RNAs that target a therapeutically important messenger RNA molecule. Messenger RNAs (mRNAs) represent a necessary step in gene expression, being the intermediate between gene and protein.

  1. John J. Rossi is in the Division of Molecular Biology, Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA.
    e-mail: Email: jrossi@bricoh.edu