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Nature 432, 155-156 (11 November 2004) | doi:10.1038/432155a; Published online 10 November 2004
Medicine: A cholesterol connection in RNAi
John J. Rossi1
Abstract
RNA interference — RNAi for short — might provide a way to silence disease-associated genes, but problems of delivery have hampered progress. Those problems may have been solved, at least in animal studies.
On page 173 of this issue, Soutschek et al.1 describe a simple but effective method for the intravenous delivery of nucleic acids called short interfering RNAs that target a therapeutically important messenger RNA molecule. Messenger RNAs (mRNAs) represent a necessary step in gene expression, being the intermediate between gene and protein.
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