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From the following article:

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

Jürgen Soutschek, Akin Akinc, Birgit Bramlage, Klaus Charisse, Rainer Constien, Mary Donoghue, Sayda Elbashir, Anke Geick, Philipp Hadwiger, Jens Harborth, Matthias John, Venkitasamy Kesavan, Gary Lavine, Rajendra K. Pandey, Timothy Racie, Kallanthottathil G. Rajeev, Ingo Röhl, Ivanka Toudjarska, Gang Wang, Silvio Wuschko, David Bumcrot, Victor Koteliansky, Stefan Limmer, Muthiah Manoharan and Hans-Peter Vornlocher

Nature 432, 173-178(11 November 2004)

doi:10.1038/nature03121

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Figure 1

Biodistribution of siRNAs in liver and jejunum.

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Figure 2

In vivo silencing of murine apoB mRNA by siRNAs in wild-type mice.

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Figure 3

Effects of siRNA administration on apoB-100 protein levels.

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Figure 4

Therapeutic reduction of lipoprotein and cholesterol levels after siRNA treatment.

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Figure 5

In vivo silencing of murine and human apoB mRNA in mice transgenic for human apoB.

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Figure 6

siRNA-mediated cleavage of apoB mRNA in vivo

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