FIGURE 5. In vivo silencing of murine and human apoB mRNA in mice transgenic for human apoB.
From the following article:
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Jürgen Soutschek, Akin Akinc, Birgit Bramlage, Klaus Charisse, Rainer Constien, Mary Donoghue, Sayda Elbashir, Anke Geick, Philipp Hadwiger, Jens Harborth, Matthias John, Venkitasamy Kesavan, Gary Lavine, Rajendra K. Pandey, Timothy Racie, Kallanthottathil G. Rajeev, Ingo Röhl, Ivanka Toudjarska, Gang Wang, Silvio Wuschko, David Bumcrot, Victor Koteliansky, Stefan Limmer, Muthiah Manoharan and Hans-Peter Vornlocher
Nature 432, 173-178(11 November 2004)
doi:10.1038/nature03121
Reduction of human and mouse apoB mRNA levels in mice transgenic for human apoB that received saline (n = 8), chol-mismatch-siRNA (n = 8) and chol-apoB-1-siRNA (n = 8). Statistical analysis was by ANOVA with Bonferroni post-hoc t-test, one-tailed. Asterisk, P < 0.0001 compared with saline and chol-mismatch-siRNA control animals. Error bars illustrate s.d. of the mean.