FIGURE 1. Biodistribution of siRNAs in liver and jejunum.
From the following article:
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Jürgen Soutschek, Akin Akinc, Birgit Bramlage, Klaus Charisse, Rainer Constien, Mary Donoghue, Sayda Elbashir, Anke Geick, Philipp Hadwiger, Jens Harborth, Matthias John, Venkitasamy Kesavan, Gary Lavine, Rajendra K. Pandey, Timothy Racie, Kallanthottathil G. Rajeev, Ingo Röhl, Ivanka Toudjarska, Gang Wang, Silvio Wuschko, David Bumcrot, Victor Koteliansky, Stefan Limmer, Muthiah Manoharan and Hans-Peter Vornlocher
Nature 432, 173-178(11 November 2004)
doi:10.1038/nature03121
An RPA was used to detect siRNAs in pooled liver and jejunum tissue lysates from animals injected with saline (- ), chol-luc-siRNA (A), chol-mismatch-siRNA (B), unconjugated apoB-1-siRNA (C2) or chol-apoB-1-siRNA (C1). Detection by RPA of endogenous miRNAs in liver (miR-122) and jejunum (miR-143) served as an internal loading control.