Table of contents
Volume 432 Number 7013 pp1-129
Editorials
Good eggs p1
There is no place for ageism in reproductive medicine.
doi:10.1038/432001a
Bad funding p1
The research of an environmental regulator is unlikely to win public trust if it relies on money from industrial lobby groups.
doi:10.1038/432001b
News
China takes steps to secure pole position in primate research p3
Low costs and lack of protestors draws animal researchers to Asia.
David Cyranoski
doi:10.1038/432003a
Climate change clouds commercial licence to krill p4
Antarctic crustaceans face double danger.
Emma Marris
doi:10.1038/432004a
Early embryos fuel hopes for shortcut to stem-cell creation p4
Stem-cell lines harvested from embryos just four days old.
Helen Pearson
doi:10.1038/432004b
Mouse sequencing plan aims to boost models p5
Catalogue of genetic differences between mice will aid disease research.
Helen Pearson
doi:10.1038/432005a
Green groups baulk at joining nanotechnology talks p5
International Council on Nanotechnology accused of industry bias.
Kendall Powell
doi:10.1038/432005b
EPA accused of conflict of interest over chemicals study p6
Study of pesticide effects on children under a cloud.
Geoff Brumfiel
doi:10.1038/432006a
Standing room only signals US zeal for Earth imaging p6
Earth scientists rally for radar-equipped satellites.
David Cyranoski
doi:10.1038/432006b
Beta-blocker goes on trial as asthma therapy p7
Potentially fatal drug may provide long-term relief.
Alison Abbott
doi:10.1038/432007a
British Museum bids to stop illicit traders using eBay p7
Internet auction sites a treasure trove of illegal sales.
Paula Gould
doi:10.1038/432007b
News Features
Medicinal leeches: Stuck on you p10
Recent studies are pointing the way for new uses of an ancient treatment — leeches. Helen Pilcher wades in to find out how these creatures could help the arthritic.
doi:10.1038/432010a
Marine conservation: Sink or swim p12
Can an ambitious plan to protect unique marine habitats in the open ocean turn the tide of destruction? Henry Nicholls plunges in.
doi:10.1038/432012a
Correspondence
European council should back young investigators p15
Support for junior researchers would be fair to all countries and disciplines.
Luc Van Dyck
doi:10.1038/432015a
US rules on tech transfer to foreign nationals p15
Peter Lichtenbaum
doi:10.1038/432015b
Industry funding doesn't influence our reports p15
Ruth Kava
doi:10.1038/432015c
Books and Arts
Revolutionary change p17
The French Revolution had a profound effect on the nation's science.
Bruno Belhoste and Bernadette Bensaude-Vincent review Science and Polity in France: The Revolutionary and Napoleonic Years by Charles Coulston Gillispie
doi:10.1038/432017a
A brain in the hand p18
Igor Aleksander reviews On Intelligence: How A New Understanding of The Brain Will Lead to the Creation of Truly Intelligent MachinesJeff Hawkins and Sandra Blakeslee
doi:10.1038/432018a
Playing host to evolution p19
Sunetra Gupta reviews Infectious Disease and Host–Pathogen Evolution
doi:10.1038/432019a
Populations in space and time p19
Alan Hastings reviews Ecology, Genetics, and Evolution of Metapopulations
doi:10.1038/432019b
Science in culture p20
An exhibition in London features the changing expression and representation of the face.
Jonathan Cole reviews
doi:10.1038/432020a
Essay
ConceptMaking sense p21
Proprioception: is the sensory system that supports body posture and movement also the root of our understanding of physical laws?
Victor Smetacek and Franz Mechsner
doi:10.1038/432021a
News and Views
Wandering nostrils p23
A small matter of head anatomy has long been a cause of controversy among those interested in vertebrate evolution. An answer that may prove generally palatable now emerges from an ancient fossil fish.
Philippe Janvier
doi:10.1038/432023a
Materials science: Lead-free at last p24
The most successful piezoelectric ceramics are based on lead zirconate and lead titanate. Environmental concerns over their lead content could disappear with the advent of a new ceramic that is lead-free.
Eric Cross
doi:10.1038/nature03142
100 and 50 years ago p25
doi:10.1038/432025a
Cell biology: Adhesion articulated p27
A new structure of the 'head' region of an integrin protein explains the remarkable vertical extension that enables these molecules to rise to the task of mediating cell adhesion.
A. Paul Mould and Martin J. Humphries
doi:10.1038/432027a
Land management: Forests, fires and climate p28
A new analysis of the effect of climatic variation on forest fires goes back several thousand years. One take-home message is that a one-size-fits-all forest management strategy is, literally, short-sighted.
Cathy Whitlock
doi:10.1038/432028a
Cardiovascular biology: How genes know their place p29
Amanda Tromans
doi:10.1038/432029a
Obituary: Fred Lawrence Whipple (1906–2004) p31
Donald K. Yeomans and Joseph Veverka
doi:10.1038/432031a
Brief Communications
Archaeology: Formulation of a Roman cosmetic p35
This unguent shares some surprising features with modern moisturizing creams.
R. P. Evershed, R. Berstan, F. Grew, M. S. Copley, A. J. H. Charmant, E. Barham, H. R. Mottram and G. Brown
doi:10.1038/432035a
First paragraph | Full Text | PDF (320K)
Biophysics: Water-repellent legs of water striders p36
Xuefeng Gao and Lei Jiang
doi:10.1038/432036a
First paragraph | Full Text | PDF (161K) | Supplementary information
Outlook
FertilityFertility p37
Peter Aldhous and Natalie DeWitt
doi:10.1038/432037a
The fertility riddle p38
Across the developed world, birth rates are plummeting. Is this just a social phenomenon, or is our biological fertility also declining? We don't yet know, and that is worrying, says Declan Butler.
Declan Butler
doi:10.1038/432038a
Age is no barrier... p40
Advances in reproductive medicine hint that female fertility might be extended into late middle age and beyond. But will the methods be safe? And is society ready for this demographic shift? Kendall Powell investigates.
Kendall Powell
doi:10.1038/432040a
Waiting for the second coming p43
Contraceptive research is seriously in need of revitalization.
Jerome F. Strauss, III and Michael Kafrissen
doi:10.1038/432043a
Fertility 2079 p46
Greg Bear glimpses the future of human reproduction.
doi:10.1038/432046a
Seeds of concern p48
During the past few decades, worries about environmental threats to human health have centred on the possible induction of cancers. Now risks to the male germ line, both real and potential, are also causing disquiet.
R. John Aitken, Peter Koopman and Sheena E. M. Lewis
doi:10.1038/432048a
Resourceful imprinting p53
A child's genes are not all equal: in some cases, the copy from either the mother or the father is turned off. This affects the child's ability to acquire resources in the womb, after birth, and perhaps throughout life.
Miguel Constância, Gavin Kelsey and Wolf Reik
doi:10.1038/432053a
Articles
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics p59
Tsan Xiao, Junichi Takagi, Barry S. Coller, Jia-Huai Wang and Timothy A. Springer
doi:10.1038/nature02976
Abstract | Full Text | PDF (674K) | Supplementary information
See also: News and Views by Mould & Humphries
Insights into assembly from structural analysis of bacteriophage PRD1 p68
Nicola G. A. Abrescia, Joseph J. B. Cockburn, Jonathan M. Grimes, Geoffrey C. Sutton, Jonathan M. Diprose, Sarah J. Butcher, Stephen D. Fuller, Carmen San Martín, Roger M. Burnett, David I. Stuart, Dennis H. Bamford and Jaana K. H. Bamford
doi:10.1038/nature03056
Abstract | Full Text | PDF (484K) | Supplementary information
Letters to Nature
High-energy particle acceleration in the shell of a supernova remnant p75
F. A. Aharonian, A. G. Akhperjanian, K.-M. Aye, A. R. Bazer-Bachi, M. Beilicke, W. Benbow, D. Berge, P. Berghaus, K. Bernlöhr, O. Bolz, C. Boisson, C. Borgmeier, F. Breitling, A. M. Brown, J. Bussons Gordo, P. M. Chadwick, V. R. Chitnis, L.-M. Chounet, R. Cornils, L. Costamante, B. Degrange, A. Djannati-Ataï, L. O'C. Drury, T. Ergin, P. Espigat, F. Feinstein, P. Fleury, G. Fontaine, S. Funk, Y. A. Gallant, B. Giebels, S. Gillessen, P. Goret, J. Guy, C. Hadjichristidis, M. Hauser, G. Heinzelmann, G. Henri, G. Hermann, J. A. Hinton, W. Hofmann, M. Holleran, D. Horns, O. C. de Jager, I. Jung, B. Khélifi, Nu. Komin, A. Konopelko, I. J. Latham, R. Le Gallou, M. Lemoine, A. Lemière, N. Leroy, T. Lohse, A. Marcowith, C. Masterson, T. J. L. McComb, M. de Naurois, S. J. Nolan, A. Noutsos, K. J. Orford, J. L. Osborne, M. Ouchrif, M. Panter, G. Pelletier, S. Pita, M. Pohl, G. Pühlhofer, M. Punch, B. C. Raubenheimer, M. Raue, J. Raux, S. M. Rayner, I. Redondo, A. Reimer, O. Reimer, J. Ripken, M. Rivoal, L. Rob, L. Rolland, G. Rowell, V. Sahakian, L. Saugé, S. Schlenker, R. Schlickeiser, C. Schuster, U. Schwanke, M. Siewert, H. Sol, R. Steenkamp, C. Stegmann, J.-P. Tavernet, C. G. Théoret, M. Tluczykont, D. J. van der Walt, G. Vasileiadis, P. Vincent, B. Visser, H. J. Völk and S. J. Wagner
doi:10.1038/nature02960
First paragraph | Full Text | PDF (188K)
An interplanetary shock traced by planetary auroral storms from the Sun to Saturn p78
Renée Prangé, Laurent Pallier, Kenneth C. Hansen, Russ Howard, Angelos Vourlidas, Régis Courtin and Chris Parkinson
doi:10.1038/nature02986
First paragraph | Full Text | PDF (295K)
Optically programmable electron spin memory using semiconductor quantum dots p81
Miro Kroutvar, Yann Ducommun, Dominik Heiss, Max Bichler, Dieter Schuh, Gerhard Abstreiter and Jonathan J. Finley
doi:10.1038/nature03008
First paragraph | Full Text | PDF (266K) | Supplementary information
Lead-free piezoceramics p84
Yasuyoshi Saito, Hisaaki Takao, Toshihiko Tani, Tatsuhiko Nonoyama, Kazumasa Takatori, Takahiko Homma, Toshiatsu Nagaya and Masaya Nakamura
doi:10.1038/nature03028
First paragraph | Full Text | PDF (1,049K)
Fire-induced erosion and millennial-scale climate change in northern ponderosa pine forests p87
Jennifer L. Pierce, Grant A. Meyer and A. J. Timothy Jull
doi:10.1038/nature03058
First paragraph | Full Text | PDF (408K) | Supplementary information
See also: News and Views by Whitlock
Contrasting origins of the upper mantle revealed by hafnium and lead isotopes from the Southeast Indian Ridge p91
Barry B. Hanan, Janne Blichert-Toft, Douglas G. Pyle and David M. Christie
doi:10.1038/nature03026
First paragraph | Full Text | PDF (354K) | Supplementary information
The origin of the internal nostril of tetrapods p94
Min Zhu and Per E. Ahlberg
doi:10.1038/nature02843
First paragraph | Full Text | PDF (281K) | Supplementary information
See also: News and Views by Janvier
Ecosystem remodelling among vertebrates at the Permian–Triassic boundary in Russia p97
M. J. Benton, V. P. Tverdokhlebov and M. V. Surkov
doi:10.1038/nature02950
First paragraph | Full Text | PDF (634K) | Supplementary information
Long-term decline in krill stock and increase in salps within the Southern Ocean p100
Angus Atkinson, Volker Siegel, Evgeny Pakhomov and Peter Rothery
doi:10.1038/nature02996
First paragraph | Full Text | PDF (1,503K) | Supplementary information
Adaptive divergence in pigment composition promotes phytoplankton biodiversity p104
Maayke Stomp, Jef Huisman, Floris de Jongh, Annelies J. Veraart, Daan Gerla, Machteld Rijkeboer, Bas W. Ibelings, Ute I. A. Wollenzien and Lucas J. Stal
doi:10.1038/nature03044
First paragraph | Full Text | PDF (314K)
Baf60c is essential for function of BAF chromatin remodelling complexes in heart development p107
Heiko Lickert, Jun K. Takeuchi, Ingo von Both, Johnathon R. Walls, Fionnuala McAuliffe, S. Lee Adamson, R. Mark Henkelman, Jeffrey L. Wrana, Janet Rossant and Benoit G. Bruneau
doi:10.1038/nature03071
First paragraph | Full Text | PDF (468K) | Supplementary information
A faux 3'-UTR promotes aberrant termination and triggers nonsense- mediated mRNA decay p112
Nadia Amrani, Robin Ganesan, Stephanie Kervestin, David A. Mangus, Shubhendu Ghosh and Allan Jacobson
doi:10.1038/nature03060
First paragraph | Full Text | PDF (482K) | Supplementary information
Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase p118
Ralf Thoma, Tanja Schulz-Gasch, Brigitte D'Arcy, Jörg Benz, Johannes Aebi, Henrietta Dehmlow, Michael Hennig, Martine Stihle and Armin Ruf
doi:10.1038/nature02993
First paragraph | Full Text | PDF (365K) | Supplementary information
Membrane structure and interactions with protein and DNA in bacteriophage PRD1 p122
Joseph J. B. Cockburn, Nicola G. A. Abrescia, Jonathan M. Grimes, Geoffrey C. Sutton, Jonathan M. Diprose, James M. Benevides, George J. Thomas, Jr, Jaana K. H. Bamford, Dennis H. Bamford and David I. Stuart
doi:10.1038/nature03053
First paragraph | Full Text | PDF (253K) | Supplementary information
Naturejobs
ProspectsHome and away p127
Paul Smaglik
doi:10.1038/nj7013-127a
Regions
High road to Scotland p128
Paul Smaglik
doi:10.1038/nj7013-128a