A new structure of the ‘head’ region of an integrin protein explains the remarkable vertical extension that enables these molecules to rise to the task of mediating cell adhesion.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins
Scientific Reports Open Access 11 January 2017
-
Dynamic regulation of integrin activation by intracellular and extracellular signals controls oligodendrocyte morphology
BMC Biology Open Access 12 November 2005
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Carman, C. V. & Springer, T. A. Curr. Opin. Cell Biol. 15, 547–556 (2003).
Mould, A. P. & Humphries, M. J. Curr. Opin. Cell Biol. 16, 544–551 (2004).
Xiao, T., Takagi, J., Coller, B. S., Wang, J. -H. & Springer, T. A. Nature 432, 59–67 (2004).
Xiong, J. -P. et al. Science 294, 339–345 (2001).
Liddington, R. C. Structure 10, 605–607 (2002).
Beglova, N. et al. Nature Struct. Biol. 9, 282–287 (2002).
Takagi, J., Petre, B. M., Walz, T. & Springer, T. A. Cell 110, 599–611 (2002).
Chigaev, A. et al. Biophys. J. 85, 3951–3962 (2003).
Mould, A. P. et al. J. Biol. Chem. 278, 17028–17035 (2003).
Xiong, J. -P. et al. Science 296, 151–155 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mould, A., Humphries, M. Adhesion articulated. Nature 432, 27–28 (2004). https://doi.org/10.1038/432027a
Published:
Issue Date:
DOI: https://doi.org/10.1038/432027a