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Nature 431, 1002-1007 (29 September 2004) | doi:10.1038/nature02994;

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Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells

Haematopoietic stem cells (HSCs) sustain blood production throughout life. HSCs are capable of extensive proliferative expansion, as a single HSC may reconstitute lethally irradiated hosts.

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