Editorial

Going public p883

Should scientists let the public help them decide how government research funds are spent? Yes they should, because the consequences are to be welcomed, not feared.

doi:10.1038/431883a

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News

Biologists seek consensus on guidelines for stem-cell research p885

Scientists debate ethics of experiments that mix mice and men.

Erika Check

doi:10.1038/431885a

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Infertility specialists counsel caution over frozen eggs p886

Reproduction techniques not ready for prime time.

Helen Pearson

doi:10.1038/431886a

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Early success claimed for Zerhouni's NIH roadmap p886

Reform of US biomedical research is well on the way.

Meredith Wadman

doi:10.1038/431886b

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Russians fear privatization of state labs p887

Thousands could lose jobs in proposed restructuring.

Bryon MacWilliams

doi:10.1038/431887a

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French delegation strengthens bond with China p887

Chirac signs up for research collaborations.

David Cyranoski

doi:10.1038/431887b

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Schwarzenegger endorses stem-cell push p888

Arnie backs measure to fund stem-cell research in California.

Jonathan Knight

doi:10.1038/431888a

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Germany balks at funding ESA's planetary ambitions p888

Aurora programme faces funding shortfall.

Alison Abbott

doi:10.1038/431888b

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Quarrel over book leads to call for misconduct inquiry p889

Born to Rebel author comes under heavy fire.

Rex Dalton

doi:10.1038/431889a

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Germany's junior professors fight for their rights p889

Young researchers battle to get their titles back.

Quirin Schiermeier

doi:10.1038/431889b

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News in Brief p890

doi:10.1038/431890a

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News Features

Antibiotics: A shot in the arm p892

Antibiotics are failing and drug companies have all but stopped developing new ones. Will conquered diseases come back to haunt us? Martin Leeb examines one plan to avert the crisis.

doi:10.1038/431892a

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Genetics: Deaf by design p894

Employing genetic diagnosis to avoid having a baby with a disability is controversial enough. But a minority of deaf people would consider testing to ensure that they had a deaf child. Carina Dennis finds out why.

doi:10.1038/431894a

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Correspondence

The real dirty secret of academic publishing p897

You can get almost anything into print if you go far enough down the ranks of journals.

Vladimir Svetlov

doi:10.1038/431897a

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US restrictions limit anthrax networking p897

Amanda Ozin, Karen Bade and Stefan H. E. Kaufmann

doi:10.1038/431897b

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Today is the time to take environmental action p897

Katrina Brown, and the TDAT group

doi:10.1038/431897c

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Commentary

Antibiotics at the crossroads p899

Are we making the right choices to bring new drugs to the marketplace?

doi:10.1038/431899a

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Autumn Books

The evolutionist's tale p903

A journey back through our evolution with a growing band of ancestors.

Jerry A. Coyne reviews The Ancestor's Tale: A Pilgrimage to the Dawn of Life by Richard Dawkins

doi:10.1038/431903a

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First steps in science p904

Paul L. Harris reviews Curious Minds: How a Child Becomes a Scientist

doi:10.1038/431904a

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Stalking life's second secret p905

Lee M. Silver reviews The Proteus Effect: Stem Cells and their Promise for Medicine by Ann B. Parson

doi:10.1038/431905a

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Food for thought for geneticists p907

T. Colin Campbell reviews Why Some Like It Hot: Food, Genes and Cultural Diversity by Gary Paul Nabhan

doi:10.1038/431907a

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The sincerest form of flattery p908

John Doyle and Marie Csete review Imitation of Life: How Biology is Inspiring Computing by Nancy Forbes

doi:10.1038/431908a

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The roots of nitrogen fixation p909

Vaclav Smil reviews The World's Greatest Fix: A History of Nitrogen in Agriculture by G. J. Leigh

doi:10.1038/431909a

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Freedom from smallpox? p911

Hugh Pennington reviews The Life and Death of Smallpox by Ian Glynn and Jenifer Glynn

doi:10.1038/431911a

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Essay

Climbing the co-evolution ladder p913

Co-evolution: Earth history involves tightly entwined transitions of information and the environment, but where is this process heading?

T. M. Lenton, H. J. Schellnhuber and E. Szathmáry

doi:10.1038/431913a

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News and Views

Human genome:  End of the beginning p915

Just over three years ago, it was announced that a first draft of the human genome sequence had been completed. Gaps and errors remained, but the job of fixing those problems is now largely done.

Lincoln D. Stein

doi:10.1038/431915a

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Comparative genomics:  Small genome, big insights p916

The genome of a second pufferfish species has been sequenced. Why is this important? Because comparing this genome with that of other animals yields a wealth of information on genome evolution.

John Mulley and Peter Holland

doi:10.1038/431916a

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100 and 50 years ago p917

doi:10.1038/431917a

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General relativity:  Frame-dragging confirmed p918

According to a prediction of general relativity, the spinning mass of the Earth affects the motion of satellites. A measurement of this 'frame-dragging' effect confirms Einstein's theory.

Neil Ashby

doi:10.1038/431918a

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Cancer:  Negative feedback for B cells p919

The discovery of a protein that regulates the production of antibody-generating B cells has implications for our understanding of how cancers of the immune system develop — and how they might be treated.

Louis M. Staudt

doi:10.1038/431919a

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Climate:  Wider connections for El Niño p920

Data from Europe in 1940–42, and simulations of severe El Niño events, suggest that the effects of such events can be unexpectedly far-reaching. The stratosphere could be a key player in this behaviour.

William J. Randel

doi:10.1038/431920a

Full Text | PDF (167K)

Physiology:  Joint approach p921

Amanda Tromans

doi:10.1038/431921a

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Obituary:  Maurice Wilkins (1916–2004) p922

Walter Gratzer

doi:10.1038/431922a

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Research highlights p923

doi:10.1038/431923a

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Brief Communications

Palaeontology:  Leg feathers in an Early Cretaceous bird p925

This feature supports the idea that the evolution of flight involved a four-winged stage.

Fucheng Zhang and Zhonghe Zhou

doi:10.1038/431925a

First paragraph | Full Text | PDF (319K)

Analysis

Shotgun sequence assembly and recent segmental duplications within the human genome p927

Xinwei She, Zhaoshi Jiang, Royden A. Clark, Ge Liu, Ze Cheng, Eray Tuzun, Deanna M. Church, Granger Sutton, Aaron L. Halpern and Evan E. Eichler

doi:10.1038/nature03062

Abstract | Full Text | PDF (158K) | Supplementary information

See also: News and Views by Stein

Articles

Finishing the euchromatic sequence of the human genome p931

International Human Genome Sequencing Consortium

doi:10.1038/nature03001

Abstract | Full Text | PDF (804K) | Supplementary information

See also: News and Views by Stein

Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype p946

Olivier Jaillon, Jean-Marc Aury, Frédéric Brunet, Jean-Louis Petit, Nicole Stange-Thomann, Evan Mauceli, Laurence Bouneau, Cécile Fischer, Catherine Ozouf-Costaz, Alain Bernot, Sophie Nicaud, David Jaffe, Sheila Fisher, Georges Lutfalla, Carole Dossat, Béatrice Segurens, Corinne Dasilva, Marcel Salanoubat, Michael Levy, Nathalie Boudet, Sergi Castellano, Véronique Anthouard, Claire Jubin, Vanina Castelli, Michael Katinka, Benoît Vacherie, Christian Biémont, Zineb Skalli, Laurence Cattolico, Julie Poulain, Véronique de Berardinis, Corinne Cruaud, Simone Duprat, Philippe Brottier, Jean-Pierre Coutanceau, Jérôme Gouzy, Genis Parra, Guillaume Lardier, Charles Chapple, Kevin J. McKernan, Paul McEwan, Stephanie Bosak, Manolis Kellis, Jean-Nicolas Volff, Roderic Guigó, Michael C. Zody, Jill Mesirov, Kerstin Lindblad-Toh, Bruce Birren, Chad Nusbaum, Daniel Kahn, Marc Robinson-Rechavi, Vincent Laudet, Vincent Schachter, Francis Quétier, William Saurin, Claude Scarpelli, Patrick Wincker, Eric S. Lander, Jean Weissenbach and Hugues Roest Crollius

doi:10.1038/nature03025

Abstract | Full Text | PDF (641K) | Supplementary information

See also: News and Views by Mulley & Holland

Letters to Nature

A confirmation of the general relativistic prediction of the Lense–Thirring effect p958

I. Ciufolini and E. C. Pavlis

doi:10.1038/nature03007

First paragraph | Full Text | PDF (185K) | Supplementary information

See also: News and Views by Ashby

Poisson's ratio and the fragility of glass-forming liquids p961

V. N. Novikov and A. P. Sokolov

doi:10.1038/nature02947

First paragraph | Full Text | PDF (152K) | Supplementary information

Low-voltage organic transistors with an amorphous molecular gate dielectric p963

Marcus Halik, Hagen Klauk, Ute Zschieschang, Günter Schmid, Christine Dehm, Markus Schütz, Steffen Maisch, Franz Effenberger, Markus Brunnbauer and Francesco Stellacci

doi:10.1038/nature02987

First paragraph | Full Text | PDF (529K) | Supplementary information

Ultra-remote stereocontrol by conformational communication of information along a carbon chain p966

Jonathan Clayden, Andrew Lund, Lluís Vallverdú and Madeleine Helliwell

doi:10.1038/nature02933

First paragraph | Full Text | PDF (460K) | Supplementary information

Extreme climate of the global troposphere and stratosphere in 1940–42 related to El Niño p971

S. Brönnimann, J. Luterbacher, J. Staehelin, T. M. Svendby, G. Hansen and T. Svenøe

doi:10.1038/nature02982

First paragraph | Full Text | PDF (325K) | Supplementary information

See also: News and Views by Randel

Release of gold-bearing fluids in convergent margin magmas prompted by magnetite crystallization p975

Weidong Sun, Richard J. Arculus, Vadim S. Kamenetsky and Raymond A. Binns

doi:10.1038/nature02972

First paragraph | Full Text | PDF (157K) | Supplementary information

A Silurian sea spider p978

Derek J. Siveter, Mark D. Sutton, Derek E. G. Briggs and David J. Siveter

doi:10.1038/nature02928

First paragraph | Full Text | PDF (317K) | Supplementary information

Performance of maximum parsimony and likelihood phylogenetics when evolution is heterogeneous p980

Bryan Kolaczkowski and Joseph W. Thornton

doi:10.1038/nature02917

First paragraph | Full Text | PDF (389K) | Supplementary information

Ecological constraints on diversification in a model adaptive radiation p984

Rees Kassen, Martin Llewellyn and Paul B. Rainey

doi:10.1038/nature02923

First paragraph | Full Text | PDF (460K) | Supplementary information

Megabase deletions of gene deserts result in viable mice p988

Marcelo A. Nóbrega, Yiwen Zhu, Ingrid Plajzer-Frick, Veena Afzal and Edward M. Rubin

doi:10.1038/nature03022

First paragraph | Full Text | PDF (447K) | Supplementary information

Neural correlates of mental rehearsal in dorsal premotor cortex p993

Paul Cisek and John F. Kalaska

doi:10.1038/nature03005

First paragraph | Full Text | PDF (370K) | Supplementary information

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells p997

Keisuke Ito, Atsushi Hirao, Fumio Arai, Sahoko Matsuoka, Keiyo Takubo, Isao Hamaguchi, Kana Nomiyama, Kentaro Hosokawa, Kazuhiro Sakurada, Naomi Nakagata, Yasuo Ikeda, Tak W. Mak and Toshio Suda

doi:10.1038/nature02989

First paragraph | Full Text | PDF (465K) | Supplementary information

Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells p1002

Hanno Hock, Melanie J. Hamblen, Heather M. Rooke, Jeffrey W. Schindler, Shireen Saleque, Yuko Fujiwara and Stuart H. Orkin

doi:10.1038/nature02994

First paragraph | Full Text | PDF (525K) | Supplementary information

Essential role for the p110 phosphoinositide 3-kinase in the allergic response p1007

Khaled Ali, Antonio Bilancio, Matthew Thomas, Wayne Pearce, Alasdair M. Gilfillan, Christine Tkaczyk, Nicolas Kuehn, Alexander Gray, June Giddings, Emma Peskett, Roy Fox, Ian Bruce, Christoph Walker, Carol Sawyer, Klaus Okkenhaug, Peter Finan and Bart Vanhaesebroeck

doi:10.1038/nature02991

First paragraph | Full Text | PDF (541K) | Supplementary information

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1 p1011

Grzegorz Ira, Achille Pellicioli, Alitukiriza Balijja, Xuan Wang, Simona Fiorani, Walter Carotenuto, Giordano Liberi, Debra Bressan, Lihong Wan, Nancy M. Hollingsworth, James E. Haber and Marco Foiani

doi:10.1038/nature02964

First paragraph | Full Text | PDF (550K) | Supplementary information

Erratum: High-resolution structure of a retroviral capsid hexameric amino-terminal domain p1017

Gulnahar B. Mortuza, Lesley F. Haire, Anthony Stevens, Stephen J. Smerdon, Jonathan P. Stoye and Ian A. Taylor

doi:10.1038/nature03065

Full Text | PDF (59K)

Naturejobs

Rewarding season p1019

Paul Smaglik

doi:10.1038/nj7011-1019a

Full Text | PDF (136K)

Boosting biotech in Finland p1020

Paul Smaglik

doi:10.1038/nj7011-1020a

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Graduate Journal:  Bridging the gap p1022

Amber Jenkins

doi:10.1038/nj7011-1022a

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Recruiters & Academia p1022

Eric Zimmerman

doi:10.1038/nj7011-1022b

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Movers p1022

doi:10.1038/nj7011-1022c

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