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Nature 431, 919-920 (21 October 2004) | doi:10.1038/431919a; Published online 20 October 2004

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Cancer:  Negative feedback for B cells

Louis M. Staudt1

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The discovery of a protein that regulates the production of antibody-generating B cells has implications for our understanding of how cancers of the immune system develop — and how they might be treated.

Some 40 years ago, Jacques Monod and François Jacob1 described the role of double-negative regulatory circuits in biological systems. In their example, two enzyme pathways each yield an end-product that inhibits the activity of the other pathway (Fig. 1a

  1. Louis M. Staudt is in the Lymphoid Malignancies Section, Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
    e-mail: Email: lstaudt@mail.nih.gov

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