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Nature 431, 919-920 (21 October 2004) | doi:10.1038/431919a; Published online 20 October 2004
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Cancer: Negative feedback for B cells
Louis M. Staudt1
Abstract
The discovery of a protein that regulates the production of antibody-generating B cells has implications for our understanding of how cancers of the immune system develop — and how they might be treated.
Some 40 years ago, Jacques Monod and François Jacob1 described the role of double-negative regulatory circuits in biological systems. In their example, two enzyme pathways each yield an end-product that inhibits the activity of the other pathway (Fig. 1a
- Louis M. Staudt is in the Lymphoid Malignancies Section, Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
e-mail: Email: lstaudt@mail.nih.gov
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