Supplementary information
From the following article:
A relative signalling model for the formation of a topographic neural map
Michaël Reber, Patrick Burrola and Greg Lemke
Nature 431, 847-853(14 October 2004)
doi:10.1038/nature02957
Supplementary Figure 1 and Discussion
This supplement elaborates on equations describing the EphA and ephrin-A gradients in the mouse, and discusses the assumption of EphA receptor interchangeability.
Supplementary Figure 1 and Discussion - Download PDF file (149KB)
Supplementary Figure 2 and Discussion
This supplement describes the direct visualization of EphA3+ axons in heterozygous knock-ins using Isl2-tlacZ as an axonal marker, and its use in multiple compound mutant backgrounds.
Supplementary Figure 2 and Discussion - Download PDF file (5.48MB)
Supplementary Figure 3 and Discussion
This supplement describes a speculative model for how ensemble-wide ratiometric
EphA comparisons may be translated into biased competition for BDNF during axonal competition and map formation in the SC.
Supplementary Figure 3 and Discussion - Download PDF file (1.17MB)
Supplementary Discussion
This supplement discusses retinal expression of ephrin-As, and the implications of results described in the text for their hypothesized roles in retinocollicular mapping.
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