Supplementary information

From the following article:

A relative signalling model for the formation of a topographic neural map

Michaël Reber, Patrick Burrola and Greg Lemke

Nature 431, 847-853(14 October 2004)

doi:10.1038/nature02957

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Supplementary Figure 1 and Discussion

This supplement elaborates on equations describing the EphA and ephrin-A gradients in the mouse, and discusses the assumption of EphA receptor interchangeability.

Supplementary Figure 2 and Discussion

This supplement describes the direct visualization of EphA3+ axons in heterozygous knock-ins using Isl2-tlacZ as an axonal marker, and its use in multiple compound mutant backgrounds.

Supplementary Figure 3 and Discussion

This supplement describes a speculative model for how ensemble-wide ratiometric sumEphA comparisons may be translated into biased competition for BDNF during axonal competition and map formation in the SC.

Supplementary Discussion

This supplement discusses retinal expression of ephrin-As, and the implications of results described in the text for their hypothesized roles in retinocollicular mapping.

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