Access
To read this story in full you will need to login or make a payment (see right).
Letters to Nature
Nature 431, 847-853 (14 October 2004) | doi:10.1038/nature02957; Received 4 June 2004; Accepted 9 August 2004
Open Innovation Challenges
-
Fast Growth of Transformed Soybean Shoots
A method for accelerating growth of soybean shoots is desired.
-
Efficient Chromosome Doubling: Plant Cell Division
The Seeker is looking for an efficient chromosome doubling method in plants and in particular, metho...
- More Challenges
- Powered by:
nature jobs
Canada Excellence Research Chair in Quantum Materials and Devices Based on Oxide Heterostructures
- University of British Columbia
- Vancouver, British Columbia Canada
Professorship in Agricultural Engineering
- University of Natural Resources and Applied Life Sciences Vienna
- Vienna, Austria
A relative signalling model for the formation of a topographic neural map
Michaël Reber, Patrick Burrola & Greg Lemke
- Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
Correspondence to: Greg Lemke Email: lemke@salk.edu
Abstract
The highly ordered wiring of retinal ganglion cell (RGC) neurons in the eye to their synaptic targets in the superior colliculus of the midbrain has long served as the dominant experimental system for the analysis of topographic neural maps1, 2, 3. Here we describe a quantitative model for the development of one arm of this map—the wiring of the nasal–temporal axis of the retina to the caudal–rostral axis of the superior colliculus. The model is based on RGC–RGC competition that is governed by comparisons of EphA receptor signalling intensity, which are made using ratios of, rather than absolute differences in, EphA signalling between RGCs4. Molecular genetic experiments, exploiting a combinatorial series of EphA receptor knock-in and knockout mice, confirm the salient predictions of the model, and show that it both describes and predicts topographic mapping.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Developmental neuroscience Two gradients are better than oneNature News and Views (05 Jan 2006)
RESEARCH
A test of the role of the proximal histidines in the Perutz model for cooperativity in haemoglobinNature Structural Biology Article (01 Jan 1997)
Verification of enhancement of the CSF space, not parenchyma, in acute stroke patients with early blood?brain barrier disruptionJournal of Cerebral Blood Flow & Metabolism Brief Communication
cAMP oscillations and retinal activity are permissive for ephrin signaling during the establishment of the retinotopic mapNature Neuroscience Article (01 Mar 2007)
See all 34 matches for Research