Supplementary information
From the following article:
Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus
Darwyn Kobasa, Ayato Takada, Kyoko Shinya, Masato Hatta, Peter Halfmann, Steven Theriault, Hiroshi Suzuki, Hidekazu Nishimura, Keiko Mitamura, Norio Sugaya, Taichi Usui, Takeomi Murata, Yasuko Maeda, Shinji Watanabe, M. Suresh, Takashi Suzuki, Yasuo Suzuki, Heinz Feldmann and Yoshihiro Kawaoka
Nature 431, 703-707(7 October 2004)
doi:10.1038/nature02951
Supplementary Figure 1
Global lung lesions caused by M88/Hsp or M88 virus. The figure shows hematoxylin-eosin staining and antigen distribution in whole lung sections on day 6 p.i. from mice infected with M88/Hsp or M88.
Supplementary Figure 2
Pathologic lesions in mice infected with WSN/HspNsp or WSN. Hematoxylin-eosin staining and detection of antigen distribution is shown on day 6 p.i.
Supplementary Figure 3
Cytokine expression in the lungs of mice infected with M88/Hsp or M88 or mock infected (PBS). This figure shows the analysis of levels of 11 cytokines on days 1, 3, 5 and 6 p.i.
Supplementary Table 1
Shown are titres of virus recovered from the lungs of mice infected with WSN/HspNsp or WSN on both days 3 and 6 p.i. to indicate that, even though pathologic lesions observed with WSN/HspNsp are much more severe than with WSN (Supplementary Fig. 2), these viruses replicate to similar titres at both timepoints.
Supplementary Table 2
The table contains the data from Fig. 4 in a nongraphical form to allow direct comparison of the neutralization titres of each serum serum sample against WSN/HspNsp and a recent human H1N1 virus (A/Kawasaki/233/01).
DOWNLOAD BROWSER PLUGINS AND OTHER APPLICATIONS
Movie files
PDF douments
Text documents
PostScript documents
Flash movies
Audio files
- Apple iTunes (PC or Mac)
- QuickTime Player (PC or Mac)
- Realplayer (PC or Mac)
- Windows Media player (PC only)
