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Nature 431, 637-639 (7 October 2004) | doi:10.1038/431637a; Published online 6 October 2004

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Molecular biology: No exception to reversibility

Yi Zhang1

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Histone proteins, which serve as scaffolds for packaging DNA, can be modified in numerous ways. It's been thought that one modification, methylation, is irreversible — but that view must now change.

Each of our cells contains about two metres or so of DNA, which must be packed down very tightly to fit into the cell nucleus. The compact form of DNA is known as chromatin, the basic unit of which consists of DNA wrapped around an octamer of histone proteins1.

  1. Yi Zhang is in the Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA.
    Email: yi_zhang@med.unc.edu

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