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Nature 431, 599-605 (30 September 2004) | doi:10.1038/431599a; Published online 29 September 2004

RNA interference: The silent treatment

Julie Clayton1

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Biotech firms are vying to harness the potential of RNA interference. But will its impact be in finding new disease targets, or in RNA-based drugs? Julie Clayton investigates.

The hype surrounding RNA interference (RNAi) 'gene-silencing' technology has both academic labs and biotech companies firmly in its grip. RNAi is lauded as a powerful approach to gene control, with the promise of revolutionizing basic research and providing treatments for intractable conditions such as cancer and neurodegenerative disease.

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