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Essay
Nature 431, 402 (23 September 2004) | doi:10.1038/431402a; Published online 22 September 2004
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Concept Mending and malignancy
Philip A. Beachy1, Sunil S. Karhadkar1 & David M. Berman1
- The authors are affiliated with the Department of Molecular Biology and Genetics and the Howard Hughes Medical Institute (P.A.B. and S.S.K.), and with the Departments of Oncology (P.A.B. and D.M.B.), Pathology (S.S.K. and D.M.B.) and Urology (D.M.B.) at The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Abstract
Carcinogenesis and tissue repair: how might chronic tissue injury lead to the development of cancer?
The familiar sensation of heartburn — whether from greasy food or too much coffee — is caused by acid reflux from the stomach into the oesophagus and is probably harmless on an occasional basis. On the other hand, persistent heartburn can indicate lasting damage to the lining of the oesophagus, resulting in changes in the cellular architecture of the epithelium and an increased incidence of the lethal cancer oesophageal adenocarcinoma.
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