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Editorial

Nature 431, 229 (16 September 2004) | doi:10.1038/431229b; Published online 15 September 2004

How to interfere with RNA

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Using RNA to manipulate gene expression is a powerful experimental tool, but can lead researchers astray.

There are many reasons to celebrate the recent discovery of RNA interference (RNAi). The finding that small double-stranded RNA molecules can silence gene expression has had a huge impact on both biological research and technological applications.

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