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Nature 431, 338-342 (16 September 2004) | doi:10.1038/nature02872; Published online 15 September 2004
Revealing the world of RNA interference
Craig C. Mello1,2 and Darryl Conte, Jr2
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Abstract
The recent discoveries of RNA interference and related RNA silencing pathways have revolutionized our understanding of gene regulation. RNA interference has been used as a research tool to control the expression of specific genes in numerous experimental organisms and has potential as a therapeutic strategy to reduce the expression of problem genes. At the heart of RNA interference lies a remarkable RNA processing mechanism that is now known to underlie many distinct biological phenomena.
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Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Email: craig.mello@umassmed.edu - Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
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