FIGURE 4. S6K1 activation in obesity.
From the following article:
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe, Frédéric Picard, Manel Joaquin, Melanie Sticker, Stefano Fumagalli, Peter R. Allegrini, Sara C. Kozma, Johan Auwerx and George Thomas
Nature 431, 200-205(9 September 2004)
doi:10.1038/nature02866
a, S6K1 Thr 389 and S6 Ser 240/244 phosphorylation in fat of wild-type mice maintained on a NCD (- ) or HFD (+ ) for 4 months. b, IRS1 Ser 307 and Ser 636/639 phosphorylation in fat of wild-type or S6K1-/- mice maintained on a NCD (- ) or HFD (+ ). c, S6K1 Thr 389, S6 Ser 240/244, IRS1 Ser 307 and IRS1 Ser 636/639 phosphorylation in fat of wild-type, K/K Ay or ob/ob mice maintained on a NCD. d, S6K1 Thr 389 phosphorylation in fat or muscle of wild-type mice maintained on a NCD or HFD for 4 months before (- ) or after (+ ) injection of insulin (0.75 U kg-1 of body weight). All mice of each genotype (n = 3–8) in a–d were fasted for 6 h and were 6 months old. e, Model of inhibition of IRS1 signalling through activation of S6K1.
