FIGURE 3. Enhanced insulin sensitivity and insulin signalling in the absence of S6K1.
From the following article:
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe, Frédéric Picard, Manel Joaquin, Melanie Sticker, Stefano Fumagalli, Peter R. Allegrini, Sara C. Kozma, Johan Auwerx and George Thomas
Nature 431, 200-205(9 September 2004)
doi:10.1038/nature02866
a, b, Insulin tolerance test in 3-h-fasted mice on a NCD (a) or HFD (b) at 6 months of age. Asterisk, P < 0.05; double asterisk, P < 0.01. Values are mean 
s.e.m. c, Insulin receptor tyrosine phosphorylation in liver of wild-type and S6K1-/- mice before (- ) or after (+ ) insulin stimulation on a NCD or HFD. d, Level of phosphorylation of PKB Ser 473 in fat, liver and muscle (n = 3–8 for each genotype in c, d). e, Lowering S6K1 expression by siRNA potentiates insulin-induced PKB phosphorylation in HeLa cells.
