FIGURE 2. Increased mitochondria and resistance to diet-induced obesity.
From the following article:
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe, Frédéric Picard, Manel Joaquin, Melanie Sticker, Stefano Fumagalli, Peter R. Allegrini, Sara C. Kozma, Johan Auwerx and George Thomas
Nature 431, 200-205(9 September 2004)
doi:10.1038/nature02866
a, The left panels show transmission electron microscopic analysis of epididymal fat. Arrowheads indicate mitochondria and lipid droplets (L) (
5,000 magnification). The right panels show UCP1 and mCPT1 mRNA (relative values) measured by quantitative RT–PCR (see Methods). b, The left panels show transmission electron microscopic analysis of plantaris muscle ( 10,000 magnification). m, mitochondria. The right panels show PPAR-
and PGC1 mRNA levels (relative values) measured by quantitative RT–PCR. In a, b, n = 4–7; asterisk, P < 0.01; double asterisk, P < 0.001. c, Representative wild-type and S6K1-/- mice after 6 months feeding on a HFD. d, Growth curves of wild-type and S6K1-/- mice maintained on a HFD. WT, n = 11; S6K1-/-, n = 15; P < 0.001. e, Oxygen consumption (VO2) in wild-type and S6K1-/- mice maintained on a HFD for 6 months (n = 6 each genotype). f, Body fat index determined by MRI analysis of wild-type (n = 10) and S6K1-/- mice (n = 12) maintained on a HFD for 4 months. Filled symbols/columns indicate wild type; open symbols/columns, S6K1-/- mice. Values are mean 
s.e.m. Asterisk, P < 0.01; double asterisk, P < 0.001 in d–f.
