FIGURE 1. Reduced adiposity in S6K1-/- mice.
From the following article:
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe, Frédéric Picard, Manel Joaquin, Melanie Sticker, Stefano Fumagalli, Peter R. Allegrini, Sara C. Kozma, Johan Auwerx and George Thomas
Nature 431, 200-205(9 September 2004)
doi:10.1038/nature02866
a, Growth curves of wild-type and S6K1-/- mice on a NCD. Wild type, n = 11; S6K1-/-, n = 13. b, Weights of epididymal, inguinal and retroperitoneal adipose tissue (EWAT, IWAT and RWAT, respectively) and liver normalized by body weight (n = 6 each genotype). WT, wild type. c, Scanning electron microscopic (top) and histological analysis of epididymal WAT (bottom). Arrowheads indicate multi-locular adipocytes. Magnification for scanning microscopy and for histology are 
500 and 200, respectively. Mice were 6-month-old males in b and c. d, Food intake per mouse measured over 15 days (n = 12; P = 0.8) or normalized by body weight (n = 12). e, Enhanced lipolysis in S6K1-/- adipocytes. f, Oxygen consumption (VO2) in wild-type and S6K1-/- mice fed a NCD (n = 6 each genotype). All values are given as mean 
s.e.m. Asterisk, P < 0.01; double asterisk, P < 0.001. Filled symbols/columns indicate wild type; open symbols/columns, S6K1-/- mice.
