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Nature 431, 99-104 (2 September 2004) | doi:10.1038/nature02800;
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Transcriptional regulatory code of a eukaryotic genome
DNA-binding transcriptional regulators interpret the genome's regulatory code by binding to specific sequences to induce or repress gene expression. Comparative genomics has recently been used to identify potential cis-regulatory sequences within the yeast genome on the basis of phylogenetic conservation, but this information alone does not reveal if or when transcriptional regulators occupy these binding sites.
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