Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer

Cell survival guide

Nature volume 431, pages 35–36 (2004)Cite this article

A jaded observer might consider the cancer research field near maturity and surprising new results improbable. But work on the protein netrin-1 shows that unforeseen insights into cancer can still occur.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Model for the role of netrin-1 and DCC in regulating cell survival and death in the intestine, based on Mazelin and colleagues' results4.

References

  1. Serafini, T. et al. Cell 78, 409–424 (1994).

    Article  CAS  Google Scholar 

  2. Kennedy, T. E., Serafini, T., de la Torre, J. R. & Tessier-Lavigne, M. Cell 78, 425–435 (1994).

    Article  CAS  Google Scholar 

  3. Mehlen, P. & Mazelin, L. Biol. Cell 95, 425–436 (2003).

    Article  CAS  Google Scholar 

  4. Mazelin, L. et al. Nature 431, 80–84 (2004).

    Article  ADS  CAS  Google Scholar 

  5. Fearon, E. R. et al. Science 247, 49–56 (1990).

    Article  ADS  CAS  Google Scholar 

  6. Fearon, E. R. Biochim. Biophys. Acta 1288, M17–M23 (1996).

    Google Scholar 

  7. Fazeli, A. et al. Nature 386, 796–804 (1997).

    Article  ADS  CAS  Google Scholar 

  8. White, R. L. Cell 92, 591–592 (1998).

    Article  CAS  Google Scholar 

  9. Thiebault, K. et al. Proc. Natl Acad. Sci. USA 100, 4173–4178 (2003).

    Article  ADS  CAS  Google Scholar 

  10. Tanikawa, C. et al. Nature Cell Biol. 5, 216–223 (2003).

    Article  CAS  Google Scholar 

  11. Mehlen, P. et al. Nature 395, 801–804 (1998).

    Article  ADS  CAS  Google Scholar 

  12. Llambi, F., Causeret, F., Bloch-Gallego, E. & Mehlen, P. EMBO J. 20, 2715–2722 (2001).

    Article  CAS  Google Scholar 

  13. Srinivasan, K., Strickland, P., Valdes, A., Shin, G. C. & Hinck, L. Dev. Cell 4, 371–382 (2003).

    Article  CAS  Google Scholar 

  14. Yebra, M. et al. Dev. Cell 5, 695–707 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Molecular Medicine and Genetics, Departments of Internal Medicine and Pathology, University of Michigan School of Medicine and Comprehensive Cancer Center, Ann Arbor, 48109-2216, Michigan, USA

    Eric R. Fearon & Kathleen R. Cho

Authors
  1. Eric R. Fearon
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kathleen R. Cho
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fearon, E., Cho, K. Cell survival guide. Nature 431, 35–36 (2004). https://doi.org/10.1038/431035a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/431035a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing