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Nature 431, 31-32 (2 September 2004) | doi:10.1038/431031a; Published online 1 September 2004

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Cell biology:  Regulated self-cannibalism

Daniel J. Klionsky1

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Cells consume parts of themselves to survive starvation and during development. But how do they control this process of self-eating so that it begins at the right time and does not end up killing the cell?

When you are fasting or are otherwise deprived of food, your body starts to break down stored nutrients to keep essential processes and organs (such as your brain) supplied with fuel. Similarly, when a cell is deprived of nutrients it will degrade some of its own constituents to stay alive.

  1. Daniel J. Klionsky is in the Departments of Molecular, Cellular and Developmental Biology, and of Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.
    e-mail: Email: klionsky@umich.edu

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