Table of contents
Volume 430 Number 7001 pp709-813
Editorials
Fear and loathing at Los Alamos p709
The laboratory that gave birth to the nuclear bomb is caught in an unsettling downward spiral of weak leadership and dwindling staff morale.
doi:10.1038/430709a
An opportunity lost p709
No one is taking responsibility for tracking the pathological aftermath of inconclusive trials of an Alzheimer's vaccine.
doi:10.1038/430709b
News
Victims hit out at university over handling of harassment cases p711
Graduate students say university investigation damaged their careers
Erika Check
doi:10.1038/430711a
Future looks bleak for powerless Hubble device p712
But robotic mission may yet save the telescope
Tony Reichhardt
doi:10.1038/430712a
Fears grow as blood stocks pass on prions undetected p712
Transfusions could perpetuate Britain's vCJD epidemic
Michael Hopkin
doi:10.1038/430712b
Security scare puts Pluto launch at risk p713
Plutonium production slips as Los Alamos shuts down
Geoff Brumfiel
doi:10.1038/430713a
Doped athletes flex muscles against drug company p713
Former East German competitors deserve compensation, say campaigners
Karoline Schwarzberg
doi:10.1038/430713b
Slipshod approvals taint Japanese animal studies p714
Animal-rights activists expose flaws in approvals procedure
David Cyranoski
doi:10.1038/430714a
Stiffer rules required to stop commerce milking Antarctica p714
Bioprospecting could damage polar environment, say researchers
Emma Marris
doi:10.1038/430714b
Doctors seek lost data on Alzheimer's vaccine p715
Valuable resource wasted after trial shuts down
Alison Abbott
doi:10.1038/430715a
Petition fails to reverse massive price rise for AIDS drug p715
National Institutes of Health refuses to take action over treatment costs
Erika Check
doi:10.1038/430715b
News Features
Oceanography: Noah's flood p718
Did a great flood once surge into the Black Sea, forming the basis of a Biblical tale? Quirin Schiermeier investigates a computer model that has added weight to the idea.
doi:10.1038/430718a
Science in the movies: Hollywood or bust p720
Last month, a handful of scientists who have toyed with the idea of writing for the movies were given a masterclass by Tinseltown's finest. Jonathan Knight joined them.
doi:10.1038/430720a
Correspondence
Migration won't make Chinese deserts bloom p723
Diverting water is not enough. Fragile land such as Xinjiang needs care, not exploitation.
Wenwei Ren and Andrew A. Sacret
doi:10.1038/430723a
Bermuda welcomes careful prospectors p723
Jack A. Ward, Anthony Knap and Jay M. Short
doi:10.1038/430723b
Golden rule of economics yet to strike prospectors p723
David Simpson and Roger Sedjo
doi:10.1038/430723c
Commentary
Seeking a global solution p725
The Copenhagen Consensus neglects the need to tackle climate change.
doi:10.1038/430725a
Books and Arts
Unhappy pills? p727
The trials and tribulations of antidepressant drugs.
John Cornwell reviews Medicines Out of Control: Antidepressants and the Conspiracy of Goodwill by Charles Medawar and Anita Hardon and Let Them Eat Prozac: The Unhealthy Relationship between the Pharmaceutical Industry and Depression by David Healy
doi:10.1038/430727a
The King of Siluria's journey p728
Ralph O'Connor reviews Murchison's Wanderings in Russia
doi:10.1038/430728a
Theatre: Playing dirty p729
Philip Ball reviews Calculus Written by Carl Djerassi
doi:10.1038/430729a
Essay
ConceptOn the move p730
Heterogeneous catalysis: just as for enzymes, flexibility and mobility are emerging as key features of catalytically active metal surfaces.
Gabor A. Somorjai
doi:10.1038/430730a
News and Views
Nonlinear dynamics: Quantizing the classical cat p731
A mathematical analysis of a pendulum system reveals the relevance to quantum systems of the classical concept of 'monodromy' — why a falling cat always lands the right way up.
Ian Stewart
doi:10.1038/430731a
100 and 50 years ago p732
doi:10.1038/430732a
Cognitive science: Rank inferred by reason p732
Pinyon jays seem to work out how to behave towards an unfamiliar jay by watching it in encounters with members of their own flock. The findings provide clues about how cognition evolved in social animals.
Sara J. Shettleworth
doi:10.1038/430732b
Human genetics: An expression of interest p733
The baseline level of gene expression varies from person to person, but how is this determined genetically? The answer may improve our understanding of complex traits, including some genetic diseases.
Nancy J. Cox
doi:10.1038/430733a
Cell biology: Barbed ends rule p734
To explore their surroundings, cells use probes of various shapes. Whether the probes are broad and flat, or long and thin, seems to be regulated by proteins at the growing ends of actin filaments.
Dorothy A. Schafer
doi:10.1038/430734a
Biological chemistry: The making of Moco p736
Nature exploits the unique chemistry of molybdenum in many reactions. Structures of the enzyme Cnx1 reveal unexpected mechanisms for slotting the metal ion into its reactive position in the cofactor Moco.
William N. Hunter
doi:10.1038/430736a
Climate change: Models change their tune p737
Climate models are usually tuned to match observations. A new approach, in which the models are detuned instead, increases our confidence in projections of future warming.
Thomas F. Stocker
doi:10.1038/430737a
Materials science: Flame-broiled alumina p738
A method for preparing aluminate glasses and glass–ceramic composites opens up new possibilities for generating mechanically strong structural components and high-hardness coatings.
Paul F. McMillan
doi:10.1038/430738a
Brief Communications
Coral reefs: Corals' adaptive response to climate change p741
Shifting to new algal symbionts may safeguard devastated reefs from extinction.
Andrew C. Baker, Craig J. Starger, Tim R. McClanahan and Peter W. Glynn
doi:10.1038/430741a
First paragraph | Full Text | PDF (176K) | Supplementary information
Coral bleaching: Thermal adaptation in reef coral symbionts p742
Rob Rowan
doi:10.1038/430742a
First paragraph | Full Text | PDF (106K) | Supplementary information
Articles
Genetic analysis of genome-wide variation in human gene expression p743
Michael Morley, Cliona M. Molony, Teresa M. Weber, James L. Devlin, Kathryn G. Ewens, Richard S. Spielman and Vivian G. Cheung
doi:10.1038/nature02797
Abstract | Full Text | PDF (327K)
See also: News and Views by Cox
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels p748
Thomas Voets, Guy Droogmans, Ulrich Wissenbach, Annelies Janssens, Veit Flockerzi and Bernd Nilius
doi:10.1038/nature02732
Abstract | Full Text | PDF (794K) | Supplementary information
Letters to Nature
Transport of solar wind into Earth's magnetosphere through rolled-up Kelvin–Helmholtz vortices p755
H. Hasegawa, M. Fujimoto, T.-D. Phan, H. Rème, A. Balogh, M. W. Dunlop, C. Hashimoto and R. TanDokoro
doi:10.1038/nature02799
First paragraph | Full Text | PDF (451K) | Supplementary information
Room-temperature ferroelectricity in strained SrTiO3 p758
J. H. Haeni, P. Irvin, W. Chang, R. Uecker, P. Reiche, Y. L. Li, S. Choudhury, W. Tian, M. E. Hawley, B. Craigo, A. K. Tagantsev, X. Q. Pan, S. K. Streiffer, L. Q. Chen, S. W. Kirchoefer, J. Levy and D. G. Schlom
doi:10.1038/nature02773
First paragraph | Full Text | PDF (335K) | Supplementary information
Bulk glasses and ultrahard nanoceramics based on alumina and rare-earth oxides p761
A. Rosenflanz, M. Frey, B. Endres, T. Anderson, E. Richards and C. Schardt
doi:10.1038/nature02729
First paragraph | Full Text | PDF (272K) | Supplementary information
See also: News and Views by McMillan
Self-assembly of amphiphilic dendritic dipeptides into helical pores p764
Virgil Percec, Andrés E. Dulcey, Venkatachalapathy S. K. Balagurusamy, Yoshiko Miura, Jan Smidrkal, Mihai Peterca, Sami Nummelin, Ulrica Edlund, Steven D. Hudson, Paul A. Heiney, Hu Duan, Sergei N. Magonov and Sergei A. Vinogradov
doi:10.1038/nature02770
First paragraph | Full Text | PDF (1,218K) | Supplementary information
Quantification of modelling uncertainties in a large ensemble of climate change simulations p768
James M. Murphy, David M. H. Sexton, David N. Barnett, Gareth S. Jones, Mark J. Webb, Matthew Collins and David A. Stainforth
doi:10.1038/nature02771
First paragraph | Full Text | PDF (573K) | Supplementary information
See also: News and Views by Stocker
Gigantism and comparative life-history parameters of tyrannosaurid dinosaurs p772
Gregory M. Erickson, Peter J. Makovicky, Philip J. Currie, Mark A. Norell, Scott A. Yerby and Christopher A. Brochu
doi:10.1038/nature02699
First paragraph | Full Text | PDF (228K) | Supplementary information
Eocene evolution of whale hearing p776
Sirpa Nummela, J. G. M. Thewissen, Sunil Bajpai, S. Taseer Hussain and Kishor Kumar
doi:10.1038/nature02720
First paragraph | Full Text | PDF (264K) | Supplementary information
Pinyon jays use transitive inference to predict social dominance p778
Guillermo Paz-y-Miño C, Alan B. Bond, Alan C. Kamil and Russell P. Balda
doi:10.1038/nature02723
First paragraph | Full Text | PDF (237K)
See also: News and Views by Shettleworth
Complex auditory behaviour emerges from simple reactive steering p781
Berthold Hedwig and James F. A. Poulet
doi:10.1038/nature02787
First paragraph | Full Text | PDF (317K)
MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode p785
Sarah Chang, Robert J. Johnston, Jr, Christian Frøkjær-Jensen, Shawn Lockery and Oliver Hobert
doi:10.1038/nature02752
First paragraph | Full Text | PDF (466K) | Supplementary information
Reaction mechanism determines NMDA receptor response to repetitive stimulation p790
Gabriela Popescu, Antoine Robert, James R. Howe and Anthony Auerbach
doi:10.1038/nature02775
First paragraph | Full Text | PDF (786K) | Supplementary information
Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5 p793
Yongliang Zhang, Joseph N. Blattman, Norman J. Kennedy, Julie Duong, Thang Nguyen, Ying Wang, Roger J. Davis, Philip D. Greenberg, Richard A. Flavell and Chen Dong
doi:10.1038/nature02764
First paragraph | Full Text | PDF (339K) | Supplementary information
Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control p797
Eva Hernando, Zaher Nahlé, Gloria Juan, Elena Diaz-Rodriguez, Miguel Alaminos, Michael Hemann, Loren Michel, Vivek Mittal, William Gerald, Robert Benezra, Scott W. Lowe and Carlos Cordon-Cardo
doi:10.1038/nature02820
First paragraph | Full Text | PDF (612K) | Supplementary information
Structure of the molybdopterin-bound Cnx1G domain links molybdenum and copper metabolism p803
Jochen Kuper, Angel Llamas, Hans-Jürgen Hecht, Ralf R. Mendel and Günter Schwarz
doi:10.1038/nature02681
First paragraph | Full Text | PDF (655K) | Supplementary information
See also: News and Views by Hunter
Electron microscopic analysis of KvAP voltage-dependent K+ channels in an open conformation p806
Qiu-Xing Jiang, Da-Neng Wang and Roderick MacKinnon
doi:10.1038/nature02735
First paragraph | Full Text | PDF (469K) | Supplementary information
Corrigendum: Reduction of hysteresis losses in the magnetic refrigerant Gd5Ge2Si2 by the addition of iron p810
Virgil Provenzano, Alexander J. Shapiro and Robert D. Shull
doi:10.1038/nature02867
Corrigendum: Enzymic activation and transfer of fatty acids and acyl-adenylates in mycobacteria p810
Omita A. Trivedi, Pooja Arora, Vijayalakshmi Sridharan, Rashmi Tickoo, Debasisa Mohanty and Rajesh S. Gokhale
doi:10.1038/nature02869
Naturejobs
ProspectsMaking the switch p811
Paul Smaglik
doi:10.1038/nj7001-811a
Postdocs
Networking, Networking, Networking, Networking, Networking p812
Drinks with a few dozen friends or a visit to an interesting employer: Myrna Watanabe meets groups finding informal ways into work.
Myrna Watanabe
doi:10.1038/nj7001-812a