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From the following article:

The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels

Thomas Voets, Guy Droogmans, Ulrich Wissenbach, Annelies Janssens, Veit Flockerzi & Bernd Nilius

Nature 430, 748-754(12 August 2004)

doi:10.1038/nature02732

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Outward rectification of TRPM8 is due to voltage-dependent gating.

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Figure 2

Cooling activates TRPM8 by shifting the voltage dependence of activation.

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Figure 3

Heating activates TRPV1 by shifting the voltage dependence of activation.

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Figure 4

A two-state model accurately predicts the temperature-dependent behaviour of TRPM8 and TRPV1.

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Figure 5

Menthol shifts the TRPM8 activation curve.

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Figure 6

Capsaicin shifts the TRPV1 activation curve.

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