FIGURE 2. Cooling activates TRPM8 by shifting the voltage dependence of activation.
From the following article:
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
Thomas Voets, Guy Droogmans, Ulrich Wissenbach, Annelies Janssens, Veit Flockerzi & Bernd Nilius
Nature 430, 748-754(12 August 2004)
doi:10.1038/nature02732
a, Whole-cell TRPM8 currents at +100 and -80 mV in response to slow cooling of the bath solution. b, Normalized current responses at +100 and -80 mV in function of temperature. c, Current traces at different temperatures in response to the indicated voltage protocol. d, Steady-state activation curves at different temperatures for the currents shown in c. The apparent Popen in function of voltage was determined as explained in the methods section. Lines represent Boltzmann functions fitted to the data. e, V1/2 as a function of temperature (n values between 6 and 15). Dashed line represents the change in V1/2 as predicted by the two-state model.
