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Nature 430, 686-689 (14 July 2004) | doi:10.1038/nature02789;
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- University Hospitals Case Medical Center
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Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref.
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