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Nature 430, 520-521 (29 July 2004) | doi:10.1038/430520b; Published online 28 July 2004
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Molecular biology: Cohesins slip sliding away
Karen E. Ross1 & Orna Cohen-Fix1
Abstract
Cohesin complexes have a central role in cell division, mediating the association between sister chromosomes. It now seems that cohesin binding is dynamic, adapting to changes in gene transcription.
Dividing cells face the monumental task of providing each progeny cell with a complete and accurate copy of the genome. During mitosis, the basic cell-division process, cells need to ensure that they send only one copy of every chromosome to each of the daughter cells.
- Karen E. Ross and Orna Cohen-Fix are at the Laboratory of Molecular and Cellular Biology, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
e-mails: Email: kross@helix.nih.gov Email: ornacf@helix.nih.gov
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