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Nature 430, 209-213 (8 July 2004) | doi:10.1038/nature02746;
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Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia
A highly pathogenic avian influenza virus, H5N1, caused disease outbreaks in poultry in China and seven other east Asian countries between late 2003 and early 2004; the same virus was fatal to humans in Thailand and Vietnam. Here we demonstrate a series of genetic reassortment events traceable to the precursor of the H5N1 viruses that caused the initial human outbreak in Hong Kong in 1997 (refs 2–4) and subsequent avian outbreaks in 2001 and 2002 (refs 5, 6).
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