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Editorials

Conflicts at the NIH (cont.) p1

Previous assurances by the director of the US National Institutes of Health to Congress over the regulation of conflicts of interest are contradicted by fresh allegations. Tough new rules for staff seem essential to restore public confidence.

doi:10.1038/430001a


Risks of high winds p1

Proponents of turbines on top of New York's Freedom Tower had better get their sums right.

doi:10.1038/430001b


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News

Earth science loses autonomy as NASA switches focus to the Moon p3

Tony Reichhardt

doi:10.1038/430003a


Kerry promises spectrum sale to fund science p4

Geoff Brumfiel

doi:10.1038/430004a


Increasing virulence of bird flu threatens mammals p4

Helen Pilcher

doi:10.1038/430004b


UN urged to use science in fight against food shortfall p5

Helen Pearson

doi:10.1038/430005a


Research cloning gets green light from Japanese ethicists p5

David Cyranoski

doi:10.1038/430005b


Weapons plan gives United Nations key role p6

Geoff Brumfiel

doi:10.1038/430006a


Santa Cruz brush-off leaves artists in a different class p6

Jonathan Knight

doi:10.1038/430006b


Junior biologists score partial victory over lab conditions p7

Alison Abbott

doi:10.1038/430007a


Academics seek to cast peer review as a public service p7

Declan Butler

doi:10.1038/430007b


News in brief p8

doi:10.1038/430008a


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News Features

Mario Capecchi: From rags to research p10

As a child, geneticist Mario Capecchi had to fight for survival after his mother was imprisoned by the Nazis. He tells his story to Carina Dennis, hoping to inspire others from a disadvantaged background.

doi:10.1038/430010a


Urban wind power:  Breezing into town p12

The world's highest urban wind farm could be a flagship project for renewable energy, if New York City planners get their way. Are city dwellers ready for wind power? Jonathan Knight investigates.

doi:10.1038/430012a


Neuroscience:  Change of mind p14

A brain haemorrhage turned an ex-convict into an obsessive artist. Jim Giles meets him and the scientists studying his case.

doi:10.1038/430014a


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Correspondence

People power against climate change p15

Local government and communities needn't wait for the big players to decide on action.

Jim Gillon

doi:10.1038/430015a


Ground rules for dealing with anthropomorphism p15

Gordon M. Burghardt

doi:10.1038/430015b


Political interference not needed in Iraqi science p15

Robert May

doi:10.1038/430015c


No joke when a technical fault fools readers p15

Michael Heather

doi:10.1038/430015d


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Books and Arts

The vehicle takes the wheel p17

Can our brains wrest control from our genes to put our own interests first?

Valerie M. Chase reviews The Robot's Rebellion: Finding Meaning in the Age of Darwin by Keith E. Stanovich

doi:10.1038/430017a


A chrestomathy on fishes p18

John C. Avise reviews Darwin's Fishes: An Encyclopedia of Ichthyology, Ecology and Evolution by Daniel Pauly

doi:10.1038/430018a


Infinite beauty p18

Kenneth Falconer reviews Fractals and Chaos: The Mandelbrot Set and Beyond by Benoit B. Mandelbrot

doi:10.1038/430018b


Science in culture p19

Medical drawings bring a new dimension to the Royal Academy's Summer Exhibition in London.

Martin Kemp reviews

doi:10.1038/430019a


Living machinery p20

Christof M. Niemeyer reviews Bionanotechnology: Lessons from Nature by David S. Goodsell

doi:10.1038/430020a


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Essay

Concept

A model for madness? p21

Dream consciousness: our understanding of the neurobiology of sleep offers insight into abnormalities in the waking brain.

Allan Hobson

doi:10.1038/430021a


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News and Views

Circadian rhythms: As time glows by in bacteria p23

Populations of cells can exhibit remarkably precise and stable circadian oscillations. But can single cells achieve such precision in the absence of intercellular communication? For cyanobacteria, it seems so.

Carl Hirschie Johnson

doi:10.1038/430023a


Extrasolar planets:  Too close for comfort p24

Three gas-giant planets have now been found in puzzlingly close orbits around their stars. These 'very hot Jupiters' raise questions about planet-finding methods and our understanding of planetary systems.

Gibor Basri

doi:10.1038/430024a


Evolutionary genomics:  Seeing double p25

How do genomes evolve? Studies of numerous yeast species confirm the view that the duplication of genes, larger chromosomal segments and whole genomes are key mechanisms.

André Goffeau

doi:10.1038/430025a


Palaeoclimate:  Message from the fish teeth p26

An innovative analysis of isotope signatures in fish fossils will help in understanding past ocean circulation and its role in the climate system, and in testing models for climate reconstruction.

Bernhard Diekmann

doi:10.1038/430026a


Neurobiology:  Sleep on it p27

Is the function of sleep to replenish energy resources or to modify neural connections in the brain? Recordings of the brain's 'reverberating circuits' evident during sleep shed light on the question.

Ilana S. Hairston and Robert T Knight

doi:10.1038/430027a


100 and 50 years ago p27

doi:10.1038/430027b


Astronomy:  Where are Procyon's quakes? p29

The acoustic waves that ripple through the Sun should exist in other stars too. But a search for these 'starquakes' in the nearby star Procyon has found no evidence of them.

Jørgen Christensen-Dalsgaard and Hans Kjeldsen

doi:10.1038/430029a


Cancer:  Understanding the target p30

The complicated responses of lung-cancer patients to a particular drug — gefitinib — are now less puzzling. Mutations in the target gene help to explain why the treatment works in some cases but not in others.

Michael R. Stratton and P. Andrew Futreal

doi:10.1038/430030a


Research highlights p31

doi:10.1038/430031a


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Brief Communications

Pterosaurs as part of a spinosaur diet p33

A rare fossilized action snapshot captures a mortal tussle with a hungry predator.

Eric Buffetaut, David Martill and François Escuillié

doi:10.1038/430033a


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Brief Communications Arising

Biodiversity conservation:  Uncertainty in predictions of extinction risk

Wilfried Thuiller, Miguel B. Araújo, Richard G. Pearson, Robert J. Whittaker, Lluís Brotons and Sandra Lavorel

doi:10.1038/nature02716


Biodiversity conservation:  Effects of changes in climate and land use

Lauren B. Buckley and Joan Roughgarden

doi:10.1038/nature02717


Biodiversity conservation:  Climate change and extinction risk

John Harte, Annette Ostling, Jessica L. Green and Ann Kinzig

doi:10.1038/nature02718


Biodiversity conservation:  Uncertainty in predictions of extinction risk/Effects of changes in climate and land use/Climate change and extinction risk (reply)

Chris D. Thomas, Stephen E. Williams, Alison Cameron, Rhys E. Green, Michel Bakkenes, Linda J. Beaumont, Yvonne C. Collingham, Barend F. N. Erasmus, Marinez Ferreira de Siqueira, Alan Grainger, Lee Hannah, Lesley Hughes, Brian Huntley, Albert S. van Jaarsveld, Guy F. Midgley, Lera Miles, Miguel A. Ortega-Huerta, A. Townsend Peterson and Oliver L. Phillips

doi:10.1038/nature02719


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Articles

Genome evolution in yeasts p35

Bernard Dujon, David Sherman, Gilles Fischer, Pascal Durrens, Serge Casaregola, Ingrid Lafontaine, Jacky de Montigny, Christian Marck, Cécile Neuvéglise, Emmanuel Talla, Nicolas Goffard, Lionel Frangeul, Michel Aigle, Véronique Anthouard, Anna Babour, Valérie Barbe, Stéphanie Barnay, Sylvie Blanchin, Jean-Marie Beckerich, Emmanuelle Beyne, Claudine Bleykasten, Anita Boisramé, Jeanne Boyer, Laurence Cattolico, Fabrice Confanioleri, Antoine de Daruvar, Laurence Despons, Emmanuelle Fabre, Cécile Fairhead, Hélène Ferry-Dumazet, Alexis Groppi, Florence Hantraye, Christophe Hennequin, Nicolas Jauniaux, Philippe Joyet, Rym Kachouri, Alix Kerrest, Romain Koszul, Marc Lemaire, Isabelle Lesur, Laurence Ma, Héloïse Muller, Jean-Marc Nicaud, Macha Nikolski, Sophie Oztas, Odile Ozier-Kalogeropoulos, Stefan Pellenz, Serge Potier, Guy-Franck Richard, Marie-Laure Straub, Audrey Suleau, Dominique Swennen, Fredj Tekaia, Micheline Wésolowski-Louvel, Eric Westhof, Bénédicte Wirth, Maria Zeniou-Meyer, Ivan Zivanovic, Monique Bolotin-Fukuhara, Agnès Thierry, Christiane Bouchier, Bernard Caudron, Claude Scarpelli, Claude Gaillardin, Jean Weissenbach, Patrick Wincker and Jean-Luc Souciet

doi:10.1038/nature02579

See also: News and Views by Goffeau


Crystal structure of a self-splicing group I intron with both exons p45

Peter L. Adams, Mary R. Stahley, Anne B. Kosek, Jimin Wang and Scott A. Strobel

doi:10.1038/nature02642


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Letters to Nature

No stellar p-mode oscillations in space-based photometry of Procyon p51

Jaymie M. Matthews, Rainer Kusching, David B. Guenther, Gordon A. H. Walker, Anthony F.J. Moffat, Slavek M. Rucinski, Dimitar Sasselov and Werner W. Weiss

doi:10.1038/nature02671

See also: News and Views by Christensen-Dalsgaard & Kjeldsen


Experimental demonstration of five-photon entanglement and open-destination teleportation p54

Zhi Zhao, Yu-Ao Chen, An-Ning Zhang, Tao Yang, Hans J. Briegel and Jian-Wei Pan

doi:10.1038/nature02643


Cyclotron frequency shifts arising from polarization forces p58

James K. Thompson, Simon Rainville and David E. Pritchard

doi:10.1038/nature02682


Single-crystal metallic nanowires and metal/semiconductor nanowire heterostructures p61

Yue Wu, Jie Xiang, Chen Yang, Wei Lu and Charles M. Lieber

doi:10.1038/nature02674


Evidence for deep-water production in the North Pacific Ocean during the early Cenozoic warm interval p65

Deborah J. Thomas

doi:10.1038/nature02639

See also: News and Views by Diekmann


Role of metal-reducing bacteria in arsenic release from Bengal delta sediments p68

Farhana S. Islam, Andrew G. Gault, Christopher Boothman, David A. Polya, John M. Charnock, Debashis Chatterjee and Jonathan R. Lloyd

doi:10.1038/nature02638


Why large-scale climate indices seem to predict ecological processes better than local weather p71

T. B. Hallett, T. Coulson, J. G. Pilkington, T. H. Clutton-Brock, J. M. Pemberton and B. T. Grenfell

doi:10.1038/nature02708


Microbialite resurgence after the Late Ordovician extinction p75

Peter M. Sheehan and Mark T. Harris

doi:10.1038/nature02654


Local sleep and learning p78

Reto Huber, M. Felice Ghilardi, Marcello Massimini and Giulio Tononi

doi:10.1038/nature02663

See also: News and Views by Hairston & Knight


Resilient circadian oscillator revealed in individual cyanobacteria p81

Irina Mihalcescu, Weihong Hsing and Stanislas Leibler

doi:10.1038/nature02533

See also: News and Views by Johnson


Evolutionary changes in cis and trans gene regulation p85

Patricia J. Wittkopp, Belinda K. Haerum and Andrew G. Clark

doi:10.1038/nature02698


Evidence for dynamically organized modularity in the yeast protein–protein interaction network p88

Jing-Dong J. Han, Nicolas Bertin, Tong Hao, Debra S. Goldberg, Gabriel F. Berriz, Lan V. Zhang, Denis Dupuy, Albertha J. M. Walhout, Michael E. Cusick, Frederick P. Roth and Marc Vidal

doi:10.1038/nature02555


PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates p93

Xiaowei Lu, Annette G. M. Borchers, Christine Jolicoeur, Helen Rayburn, Julie C. Baker and Marc Tessier-Lavigne

doi:10.1038/nature02677


Nitrification by plants that also fix nitrogen p98

Charles R. Hipkin, Deborah J. Simpson, Stephen J. Wainwright and Mansour A. Salem

doi:10.1038/nature02635


Context-dependent contributions of backbone hydrogen bonding to beta-sheet folding energetics p101

Songpon Deechongkit, Houbi Nguyen, Evan T. Powers, Philip E. Dawson, Martin Gruebele and Jeffery W. Kelly

doi:10.1038/nature02611


Corrigendum: Global-scale temperature patterns and climate forcing over the past six centuries p105

Michael E. Mann, Raymond S. Bradley and Malcolm K. Hughes

doi:10.1038/nature02478


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Technology Features

Drug discovery:  The leading edge p109

Synthesizing and selecting the lead compounds that will become the drugs of the future are the heart of drug discovery. Tim Chapman goes back to basics.

Tim Chapman

doi:10.1038/430109a


Mining the proteome p109

doi:10.1038/430109b


Proteins on the move p111

doi:10.1038/430111a


Starting from scratch p113

doi:10.1038/430113a


Table of suppliers p117

doi:10.1038/430117a


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Naturejobs

Prospects

The best years of our lives p121

Paul Smaglik

doi:10.1038/nj6995-121a


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