1. Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
2. Center for Neurobiology and Behavior, Columbia College of Physicians and Surgeons, New York, New York 10032, USA

Correspondence to: Giulio Tononi¹ Email: gtononi@wisc.edu

Abstract

Human sleep is a global state whose functions remain unclear. During much of sleep, cortical neurons undergo slow oscillations in membrane potential, which appear in electroencephalograms as slow wave activity (SWA) of <4 Hz¹. The amount of SWA is homeostatically regulated, increasing after wakefulness and returning to baseline during sleep². It has been suggested that SWA homeostasis may reflect synaptic changes underlying a cellular need for sleep³. If this were so, inducing local synaptic changes should induce local SWA changes, and these should benefit neural function. Here we show that sleep homeostasis indeed has a local component, which can be triggered by a learning task involving specific brain regions. Furthermore, we show that the local increase in SWA after learning correlates with improved performance of the task after sleep. Thus, sleep homeostasis can be induced on a local level and can benefit performance.

1. Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
2. Center for Neurobiology and Behavior, Columbia College of Physicians and Surgeons, New York, New York 10032, USA

Correspondence to: Giulio Tononi¹ Email: gtononi@wisc.edu

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.