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Editorials

Not quite shipshape p789

Japan is building a superb vessel for ocean drilling but seems reluctant to provide the necessary resources for using it. It is missing an opportunity to take a scientific lead.

doi:10.1038/429789a


PhD — club or history? p789

The decision by the University of Konstanz to retract the PhD of Jan Hendrik Schön is misguided.

doi:10.1038/429789b


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News

Biologists seek stamp of approval to send live fruitflies by post p791

David Cyranoski

doi:10.1038/429791a


Experts challenge claims for space tourism p792

Helen Pearson

doi:10.1038/429792a


RNA therapy beckons as firms prepare for clinical trials p792

Erika Check

doi:10.1038/429792b


NASA reforms needed to give Moon–Mars plan a better shot p793

Tony Reichhardt

doi:10.1038/429793a


British drug company to put data online as criticism mounts p793

Jim Giles

doi:10.1038/429793b


Biologists take degrading route to tackle cancer p794

Alison Abbott

doi:10.1038/429794a


Scots propose SUPA plan for united approach to physics p794

Jim Giles

doi:10.1038/429794b


Climate researcher takes academy hot seat p795

Geoff Brumfiel

doi:10.1038/429795a


Last-ditch funding keeps ocean drilling project afloat p795

David Cyranoski

doi:10.1038/429795b


News in brief p796

doi:10.1038/429796a


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News Features

Venomous snails:  One slip, and you're dead... p798

The lethal toxins produced by cone snails are in hot demand for neuroscience research, and are being developed as potent drugs. Laura Nelson visits a would-be snail 'farmer', for whom milking time is fraught with danger.

doi:10.1038/429798a


Ship scrapping:  Breaking up is hard to do p800

Single-hulled ships are being rushed to the scrapyard in the wake of oil spills such as that of the Prestige. But will breaking them up cause environmental havoc too? Duncan Graham-Rowe finds out.

doi:10.1038/429800a


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Correspondence

Rice, research and real life in the field p803

In the spirit of science, we should ask why studies don't reflect farmers' experiences.

A. Satyanarayana

doi:10.1038/429803a


Rice: location is vital in crop management p803

Huib Hengsdijk and Prem Bindraban

doi:10.1038/429803b


Opening the chamber of peer-review secrets p803

Erwin G. Van Meir

doi:10.1038/429803c


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Commentary

More than meets the eye p804

Earth's real biodiversity is invisible, whether we like it or not.

doi:10.1038/429804a


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Books and Arts

Paying for the pills p807

How much does it really cost to put a new drug on the market?

John E. Calfee reviews The $800 Million Pill: The Truth Behind the Cost of New Drugs by Merrill Goozner

doi:10.1038/429807a


Requiem for a supercollider p808

Geoff Brumfiel reviews A Hole in Texas by Herman Wouk

doi:10.1038/429808a


Bright blue dot p808

Douglas A. Vakoch reviews The Privileged Planet: How Our Place in the Cosmos is Designed for Discovery by Guillermo Gonzalez and Jay W. Richards

doi:10.1038/429808b


Exhibition:  Eyes that follow you around the room p809

Alan Packer

doi:10.1038/429809a


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Essay

Turning points

Mentors and manipulation p811

How Nobel assistance helped a young researcher test a crazy idea.

G. J. V. Nossal

doi:10.1038/429811a


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News and Views

Ecology:  Diversity in the deep blue sea p813

A large-scale survey of the diversity and abundance of plankton in different marine environments around the world has produced some thought-provoking similarities and contrasts with other ecosystems.

Peter J. Morin and Jeremy W. Fox

doi:10.1038/429813a


Planetary science:  How Mercury got its spin p814

The orbital period of Mercury and its period of rotation are known to be in a 3/2 ratio, but the chances of the planet reaching this state seemed so small as to be unfeasible — until now.

Stanley F. Dermott

doi:10.1038/429814a


Condensed-matter physics:  Plasmas put in order p815

Plasmas are usually a hot soup of dissociated electrons and ions. There are, however, techniques for cooling plasmas, and simulations show that an ultracold plasma could be made to crystallize.

Thomas C. Killian

doi:10.1038/429815a


Cell biology:  A channel for protein waste p817

Cells destroy misshapen proteins; viruses use the same methods to destroy healthy cellular proteins that are involved in antiviral defences. A long-sought intermediary in the process has now been uncovered.

Randy Schekman

doi:10.1038/429817a


100 and 50 years ago p817

doi:10.1038/429817b


Cometary science:  Fly-through at Wild 2 p818

The Stardust mission has made the closest approach ever to a comet. Its 'fly-through' of the gas and dust surrounding Wild 2 presents a unique opportunity to investigate the evolution of such bodies.

Michael F. A'Hearn

doi:10.1038/429818a


Heart disease:  An ongoing genetic battle? p819

Babies born with physical defects in their hearts may survive, but they often suffer defects in heart function as adults. The physical and functional problems might, it seems, have the same genetic cause.

Deepak Srivastava

doi:10.1038/429819a


Metrology:  Electrifying effects in colloids p822

The electric field generated in the sedimentation or centrifugation of charged colloidal particles could be exploited to determine the charge and the mass of macromolecules in a single experiment.

Patrick Warren

doi:10.1038/429822a


News and views in brief p823

doi:10.1038/429823a


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Brief Communications

Physiology: Hibernation in a tropical primate p825

Even in the wound-down hibernating state, this lemur can warm up without waking up.

Kathrin H. Dausmann, Julian Glos, Jörg U. Ganzhorn and Gerhard Heldmaier

doi:10.1038/429825a


Plant biochemistry:  A naturally decaffeinated arabica coffee p826

Maria B. Silvarolla, Paulo Mazzafera and Luiz C. Fazuoli

doi:10.1038/429826a


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Review

Confronting the coral reef crisis p827

D. R. Bellwood, T. P. Hughes, C. Folke and M. Nyström

doi:10.1038/nature02691


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Articles

A membrane protein required for dislocation of misfolded proteins from the ER p834

Brendan N. Lilley and Hidde L. Ploegh

doi:10.1038/nature02592

See also: News and Views by Schekman


A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol p841

Yihong Ye, Yoko Shibata, Chi Yun, David Ron and Tom A. Rapoport

doi:10.1038/nature02656

See also: News and Views by Schekman


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Letters to Nature

Mercury's capture into the 3/2 spin-orbit resonance as a result of its chaotic dynamics p848

Alexandre C. M. Correia and Jacques Laskar

doi:10.1038/nature02609

See also: News and Views by Dermott


Laser-induced ultrafast spin reorientation in the antiferromagnet TmFeO3 p850

A. V. Kimel, A. Kirilyuk, A. Tsvetkov, R. V. Pisarev and Th. Rasing

doi:10.1038/nature02659


Reduction of hysteresis losses in the magnetic refrigerant Gd5Ge2Si2 by the addition of iron p853

Virgil Provenzano, Alexander J. Shapiro and Robert D. Shull

doi:10.1038/nature02657


Evidence for a macroscopic electric field in the sedimentation profiles of charged colloids p857

Mircea Ras cedila and Albert P. Philipse

doi:10.1038/nature02672

See also: News and Views by Warren


Role of CO2 in the formation of gold deposits p860

G. N. Phillips and K. A. Evans

doi:10.1038/nature02644


Global biodiversity patterns of marine phytoplankton and zooplankton p863

Xabier Irigoien, Jef Huisman and Roger P. Harris

doi:10.1038/nature02593

See also: News and Views by Morin & Fox


Coral communities are regionally enriched along an oceanic biodiversity gradient p867

Ronald H. Karlson, Howard V. Cornell and Terence P. Hughes

doi:10.1038/nature02685


Global patterns in human consumption of net primary production p870

Marc L. Imhoff, Lahouari Bounoua, Taylor Ricketts, Colby Loucks, Robert Harriss and William T. Lawrence

doi:10.1038/nature02619


A proteoglycan mediates inductive interaction during plant vascular development p873

Hiroyasu Motose, Munetaka Sugiyama and Hiroo Fukuda

doi:10.1038/nature02613


Rapid BDNF-induced retrograde synaptic modification in a developing retinotectal system p878

Jiu-lin Du and Mu-ming Poo

doi:10.1038/nature02618


Gene regulation and DNA damage in the ageing human brain p883

Tao Lu, Ying Pan, Shyan-Yuan Kao, Cheng Li, Isaac Kohane, Jennifer Chan and Bruce A. Yankner

doi:10.1038/nature02661


Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells p891

Ge Guo, Wei Wang and Allan Bradley

doi:10.1038/nature02653


Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene p896

Kosuke Yusa, Kyoji Horie, Gen Kondoh, Michiyoshi Kouno, Yusuke Maeda, Taroh Kinoshita and Junji Takeda

doi:10.1038/nature02646


Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting p900

Masahiro Kaneda, Masaki Okano, Kenichiro Hata, Takashi Sado, Naomi Tsujimoto, En Li and Hiroyuki Sasaki

doi:10.1038/nature02633


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Naturejobs

Prospects

Stem-cell state lines p905

Paul Smaglik

doi:10.1038/nj6994-905a


Career View

Graduate Journal:  Show us the money! p906

Tshaka Cunningham

doi:10.1038/nj6994-906a


Bricks & Mortar p906

Paul Smaglik

doi:10.1038/nj6994-906b


Movers p906

doi:10.1038/nj6994-906c


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