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From the following article:

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

Frédéric Picard, Martin Kurtev, Namjin Chung, Acharawan Topark-Ngarm, Thanaset Senawong, Rita Machado de Oliveira, Mark Leid, Michael W. McBurney and Leonard Guarente

Nature 429, 771-776(17 June 2004)

doi:10.1038/nature02583

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Figure 1

Sirt1 regulates adipogenesis and triglyceride accumulation in 3T3-L1 cells.

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Figure 2

Activation of Sirt1 by resveratrol decreases fat accumulation in differentiated adipocytes.

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Figure 3

Sirt1 reduces fat accumulation by repressing PPAR-gamma activity through Sirt1–NCoR interactions.

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Figure 4

Sirt1 promotes fat mobilization in vivo.

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