Table of contents
Volume 429 Number 6991 pp487-584
Editorials
Proteomic diagnostics tested p487
Concerns about a cancer diagnostics test based on proteomics highlight the threat to public trust in healthcare products where the relevant data are not publicly available — and what can be achieved when they are.
doi:10.1038/429487a
A question of priority p487
How to sustain the reliability of the patenting system?
doi:10.1038/429487b
News
NASA devolves control of Cassini observations to research teams p489
Tony Reichhardt
doi:10.1038/429489a
Double check casts doubt on statistics in published papers p490
Helen Pearson
doi:10.1038/429490a
Korean bioethicists call for inquiry into stem-cell work p490
David Cyranoski
doi:10.1038/429490b
Fossil hunters bristle over plans for US tour p491
Rex Dalton
doi:10.1038/429491a
Scientists deny ethical breach at Kenyan orphanage p491
Declan Butler
doi:10.1038/429491b
Overseas aid policy needs better science input, inquiry finds p492
Jim Giles
doi:10.1038/429492a
Researchers seize moment to make tobacco data public p492
Michael Hopkin
doi:10.1038/429492b
Pressured staff 'lose faith' in patent quality p493
Alison Abbott
doi:10.1038/429493a
Brands in peril as Brazil strives to keep AIDS drugs free p493
Declan Butler
doi:10.1038/429493b
News Features
Proteomics and cancer: Running before we can walk? p496
Two years ago, a new proteomic test was heralded as the future of cancer diagnostics. But since then, doubts about its effectiveness have begun to grow. Erika Check reports.
doi:10.1038/429496a
Tortoise conservation: One of a kind p498
Lonesome George is probably the last giant tortoise of his type. But are scientists doing all they can to find him a partner, boost his sex drive and save his subspecies? Henry Nicholls finds out.
doi:10.1038/429498a
Correspondence
Cultural weight dragging at Asian giants' feet p501
Scientific progress is impeded by a tradition of conformity and respect for authority.
C. P. Rajendran
doi:10.1038/429501a
Ecological and political costs of river diversion p501
Anping Chen and Changdu Chen
doi:10.1038/429501b
Turing's war work counts for more than computers p501
Jürgen Schmidhuber
doi:10.1038/429501c
Books and Arts
Women in the cabinet p503
The role of women in the history of science has long been overlooked.
Jessica Riskin reviews Pandora's Breeches: Women, Science and Power in the Enlightenment by Patricia Fara
doi:10.1038/429503a
Big-game theory p504
Andrew Illius reviews The Kruger Experience: Ecology and Management of Savanna Heterogeneity
doi:10.1038/429504a
Mind the gap p505
David Papineau reviews The Physiology of Truth: Neuroscience and Human Knowledge by Jean-Pierre Changeux
doi:10.1038/429505a
Exhibition: Inspired by insects p505
doi:10.1038/429505b
Science in culture: A fluid definition of art p506
Viewing images of liquid crystals as art raises complex questions.
Martin Kemp
doi:10.1038/429506a
Essay
ConceptWhen symmetry breaks down p507
Electroweak-symmetry breaking: solving the riddle of how symmetry is broken may determine the future direction of particle physics.
Edward Witten
doi:10.1038/429507a
News and Views
Physics: The atomic wrist-watch p509
Tired of having to set your watch every now and then? Well, how about an atomic clock on your wrist? Developments in technology and timing techniques could make this a distinct possibility.
Robert Wynands
doi:10.1038/429509a
Gene regulation: A reason for reading nonsense p510
The process of transcribing DNA can itself regulate gene expression in yeast: in the case concerned it is the very act of reading the DNA, not the message produced, that carries out the regulatory job.
Sabine Schmitt and Renato Paro
doi:10.1038/429510a
Theoretical immunology: Parasitic turncoat p511
Some parasites evade the immune response of their victim by changing their antigenic coat. Surprisingly, it seems that the trick works best if the new coat isn't completely different from the old one.
Rustom Antia and Jacob Koella
doi:10.1038/429511a
Global change: Hydrocarbon-driven warming p513
A dramatic historical episode of global warming seems to have been driven by the release of huge amounts of hydrocarbons. New evidence for what might have happened comes from the sea floor off Norway.
Gerald R. Dickens
doi:10.1038/429513a
Neurobiology: A matter of balance p515
The types of chemical signal that a neuron synthesizes and communicates with were thought to be genetically encoded and largely invariable. It seems, though, that if a neuron's activity changes, so too do its signals.
Martyn Goulding
doi:10.1038/429515a
100 and 50 years ago p515
doi:10.1038/429515b
Behavioural genetics: All in the family p517
Mothers and offspring may have different ideas about how much maternal care should be provided. How is the behaviour of both parties genetically influenced, and how is this evolutionary conflict resolved?
Allen J. Moore
doi:10.1038/429517a
Correction p518
doi:10.1038/429518a
News and views in brief p519
doi:10.1038/429519a
Brief Communications
Endangered species: Where leatherback turtles meet fisheries p521
Conservation efforts should focus on hot spots frequented by these ancient reptiles.
Sandra Ferraroli, Jean-Yves Georges, Philippe Gaspar and Yvon Le Maho
doi:10.1038/429521a
First paragraph | Full Text | PDF (375K) | Supplementary information
Endangered species: Pan-Atlantic leatherback turtle movements p522
Graeme C. Hays, Jonathan D. R. Houghton and Andrew E. Myers
doi:10.1038/429522a
First paragraph | Full Text | PDF (252K) | Supplementary information
Article
Activity-dependent homeostatic specification of transmitter expression in embryonic neurons p523
Laura N. Borodinsky, Cory M. Root, Julia A. Cronin, Sharon B. Sann, Xiaonan Gu and Nicholas C. Spitzer
doi:10.1038/nature02518
Abstract | Full Text | PDF (651K) | Supplementary information
See also: News and Views by Goulding
Letters to Nature
The structure of the high-energy spin excitations in a high-transition-temperature superconductor p531
S. M. Hayden,
H. A. Mook,
Pengcheng Dai,
T. G. Perring
and
F. Do
an
doi:10.1038/nature02576
First paragraph | Full Text | PDF (700K) | Supplementary information
Quantum magnetic excitations from stripes in copper oxide superconductors p534
J. M. Tranquada, H. Woo, T. G. Perring, H. Goka, G. D. Gu, G. Xu, M. Fujita and K. Yamada
doi:10.1038/nature02574
First paragraph | Full Text | PDF (390K)
A three-dimensional optical photonic crystal with designed point defects p538
Minghao Qi, Elefterios Lidorikis, Peter T. Rakich, Steven G. Johnson, J. D. Joannopoulos, Erich P. Ippen and Henry I. Smith
doi:10.1038/nature02575
First paragraph | Full Text | PDF (436K) | Supplementary information
Release of methane from a volcanic basin as a mechanism for initial Eocene global warming p542
Henrik Svensen, Sverre Planke, Anders Malthe-Sørenssen, Bjørn Jamtveit, Reidun Myklebust, Torfinn Rasmussen Eidem and Sebastian S. Rey
doi:10.1038/nature02566
First paragraph | Full Text | PDF (347K)
See also: News and Views by Dickens
Geochemical evidence from the Sudbury structure for crustal redistribution by large bolide impacts p546
James E. Mungall, Doreen E. Ames and Jacob J. Hanley
doi:10.1038/nature02577
First paragraph | Full Text | PDF (189K)
Doubling the estimate of invertebrate biomass in a rainforest canopy p549
Martin D. F. Ellwood and William A. Foster
doi:10.1038/nature02560
First paragraph | Full Text | PDF (199K)
Unusually dynamic sex roles in a fish p551
Elisabet Forsgren, Trond Amundsen, Åsa A. Borg and Jens Bjelvenmark
doi:10.1038/nature02562
First paragraph | Full Text | PDF (174K)
Transient cross-reactive immune responses can orchestrate antigenic variation in malaria p555
Mario Recker, Sean Nee, Peter C. Bull, Sam Kinyanjui, Kevin Marsh, Chris Newbold and Sunetra Gupta
doi:10.1038/nature02486
First paragraph | Full Text | PDF (281K) | Supplementary information
See also: News and Views by Antia & Koella
Positive selection at sites of multiple amino acid replacements since rat–mouse divergence p558
Georgii A. Bazykin, Fyodor A. Kondrashov, Aleksey Y. Ogurtsov, Shamil Sunyaev and Alexey S. Kondrashov
doi:10.1038/nature02601
First paragraph | Full Text | PDF (148K) | Supplementary information
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body p562
Dae Sung Hwangbo, Boris Gersham, Meng-Ping Tu, Michael Palmer and Marc Tatar
doi:10.1038/nature02549
First paragraph | Full Text | PDF (416K) | Supplementary information
The transcriptional programme of antibody class switching involves the repressor Bach2 p566
Akihiko Muto, Satoshi Tashiro, Osamu Nakajima, Hideto Hoshino, Satoru Takahashi, Eiichirou Sakoda, Dai Ikebe, Masayuki Yamamoto and Kazuhiko Igarashi
doi:10.1038/nature02596
First paragraph | Full Text | PDF (455K) | Supplementary information
Intergenic transcription is required to repress the Saccharomyces cerevisiae SER3 gene p571
Joseph A. Martens, Lisa Laprade and Fred Winston
doi:10.1038/nature02538
First paragraph | Full Text | PDF (324K) | Supplementary information
See also: News and Views by Schmitt & Paro
Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila p575
David Gatfield and Elisa Izaurralde
doi:10.1038/nature02559
First paragraph | Full Text | PDF (331K) | Supplementary information
Cyclic electron flow around photosystem I is essential for photosynthesis p579
Yuri Munekage, Mihoko Hashimoto, Chikahiro Miyake, Ken-Ichi Tomizawa, Tsuyoshi Endo, Masao Tasaka and Toshiharu Shikanai
doi:10.1038/nature02598
First paragraph | Full Text | PDF (294K) | Supplementary information
Naturejobs
ProspectsNever-ending stories p583
Paul Smaglik
doi:10.1038/nj6991-583a
Career View
Graduate Journal: The final straight p584
Amber Jenkins
doi:10.1038/nj6991-584a
Introductory matters p584
Deb Koen
doi:10.1038/nj6991-584b
Movers p584
doi:10.1038/nj6991-584c