Supplementary information : DNA sequence and comparative analysis of chimpanzee chromosome 22 : Nature

From the following article:

DNA sequence and comparative analysis of chimpanzee chromosome 22

The International Chimpanzee Chromosome 22 Consortium

Nature 429, 382-388(27 May 2004)

doi:10.1038/nature02564

Supplementary Methods

Methodological details and supplemental data associated with them. Methods are for: mapping and sequencing, sequencing alignment, gene annotation, comparative genomics, gene expression analysis and SNP analysis.

Supplementary Methods - Download Word file (88KB)

Supplementary Tables 1 and 4–11

Table 1. Center contribution; Table 4. Genes with internal amino acid insertions or deletions in chimpanzee; Table 5. Genes with altered start or stop codons in chimpanzee; Table 6. Genes with extreme Ka/Ks values; Table 7. Genes on human chromosome 21 that show significant expression differences between humans and chimpanzees; Table 8. Ranking of all genes that were expressed in either brain or liver; Table 9. Nucleotide substitution patterns in human and chimpanzee; Table 10. List of 18 DNA regions that showed statistically significant results based on a Modified H test suggesting positive selection (bin size = 10kb); Table 11. Computational analysis of the transcription factor binding sites.

Supplementary Tables 1 and 4–11 - Download Word file (728KB)

Supplementary Table 2

Summary of PTR22q sequence quality.

Supplementary Table 2 - Download Excel file (21KB)

Supplementary Table 3

This hyperlinked file provides HSA21q and PTR22q gene annotations obtained from various comparative genomics tools. The authors will keep updating this Table that can be seen from consortium web pages.

Supplementary Table 3 - Download htm (1.15MB)