Access
To read this story in full you will need to login or make a payment (see right).
insight
Nature 429, 464-468 (27 May 2004) | doi:10.1038/nature02626
review article Moving towards individualized medicine with pharmacogenomics
William E. Evans1,2 & Mary V. Relling1,2
Abstract
Individuals respond differently to drugs and sometimes the effects are unpredictable. Differences in DNA that alter the expression or function of proteins that are targeted by drugs can contribute significantly to variation in the responses of individuals. Many of the genes examined in early studies were linked to highly penetrant, single-gene traits, but future advances hinge on the more difficult challenge of elucidating multi-gene determinants of drug response. This intersection of genomics and medicine has the potential to yield a new set of molecular diagnostic tools that can be used to individualize and optimize drug therapy.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Mapping a role for SNPs in drug developmentNature Biotechnology Research News (01 Mar 2001)
Pharmacogenetics: more than skin deepNature Genetics News and Views (01 Nov 2001)