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Brief Communications

Nature 429, 363 (27 May 2004) | doi:10.1038/429363a

Pigment chemistry:  The red sweat of the hippopotamus

Yoko Saikawa1, Kimiko Hashimoto1,2, Masaya Nakata1, Masato Yoshihara3, Kiyoshi Nagai3, Motoyasu Ida3 & Teruyuki Komiya3

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The red and orange pigments in this secretion account for its protective properties.

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Within a few minutes of perspiration, the colourless, viscous sweat of the hippopotamus gradually turns red, and then brown as the pigment polymerizes. Here we isolate and characterize the pigments responsible for this colour reaction. The unstable red and orange pigments turn out to be non-benzenoid aromatic compounds that are unexpectedly acidic and have antibiotic as well as sunscreen activity.

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