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News and Views
Nature 429, 138-139 (13 May 2004) | doi:10.1038/429138a
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Assistant Professor of Medicine
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- Boston, MA
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Signal transduction: Thumbs up for inactivation
Holger Rehmann1 & Johannes L. Bos1
Abstract
Cellular signalling pathways depend on the proper activation and inactivation of mediators. New structural information reveals an unusual mechanism by which one such mediator, Rap1, is switched off.
Proteins of the Ras family regulate a variety of cellular processes — ranging from proliferation to adhesion — in response to information received at the cell surface. These proteins, which are part of a broader class known as G proteins, are in essence simple on/off switches.
- Holger Rehmann and Johannes L. Bos are in the Department of Physiological Chemistry and the Centre for Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.
e-mail: Email: j.l.bos@med.uu.nl
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