Editorials

Carbon impacts made visible p1

Despite disagreement between governments about tackling climate change, initiatives are bubbling up from below. With help from researchers and the markets, citizens can be made more aware of how to help reduce carbon dioxide emissions.

doi:10.1038/429001a

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Ethics of therapeutic cloning p1

A moment of triumph for South Korean science appears to have been marred by doubts about lab practice.

doi:10.1038/429001b

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News

Korea's stem-cell stars dogged by suspicion of ethical breach p3

David Cyranoski

doi:10.1038/429003a

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BioShield defence programme set to fund anthrax vaccine p4

Erika Check

doi:10.1038/429004a

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NASA opens its arms to robot options for saving telescope p4

Tony Reichhardt

doi:10.1038/429004b

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Feathered fossils cause a flap in museums p5

Rex Dalton

doi:10.1038/429005a

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Top job at NSF on hold until after US elections p5

Geoff Brumfiel

doi:10.1038/429005b

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Tax change curtails UK university spin-offs p6

Jim Giles

doi:10.1038/429006a

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AIDS drug price hike prompts calls for intervention p6

Erika Check

doi:10.1038/429006b

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Global warming anomaly may succumb to microwave study p7

doi:10.1038/429007a

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Fatal fruit bat virus sparks epidemics in southern Asia p7

Declan Butler

doi:10.1038/429007b

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News in brief p8

doi:10.1038/429008a

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News Features

Physics: The waiting game p10

A few physicists have spent decades searching for the rarest events in the Universe — and seen nothing. But their enthusiasm for the hunt is undimmed. Geoff Brumfiel asks what keeps them going.

doi:10.1038/429010a

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Stem-cell research: Crunch time for Korea's cloners p12

A team in Seoul has stolen a march with its work towards human therapeutic cloning. The researchers have been fêted, but an ethical controversy may threaten their work. David Cyranoski investigates.

doi:10.1038/429012a

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Correspondence

Managing fisheries in a changing climate p15

No need to wait for more information: industrialized fishing is already wiping out stocks.

Boris Worm and Ransom A. Myers

doi:10.1038/429015a

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Colourful history of Japan's rat resources p15

Tadao Serikawa

doi:10.1038/429015b

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Multiskilled mouse rivals Renaissance rat p15

Richard A. Radcliffe

doi:10.1038/429015c

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Spring Books

The human factor p17

What is it that makes us different from other animals?

David L. Hull reviews So You Think You're Human? A Brief History of Humankind by Felipe Fernández-Armesto and The Human Story: A New History of Mankind's Evolution by Robin Dunbar

doi:10.1038/429017a

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Walking on their ribs p18

Nick Hopwood reviews Geoffroy Saint-Hilaire: A Visionary Naturalist by Hervé Le Guyader

doi:10.1038/429018a

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Sexual diversity and the gender agenda p19

Sarah Blaffer Hrdy reviews Evolution's Rainbow: Diversity, Gender and Sexuality in Nature and People Joan Roughgarden

doi:10.1038/429019a

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High points in geology p21

David E. James reviews Devil in the Mountain: A Search for the Origin of the Andes by Simon Lamb

doi:10.1038/429021a

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The way or the world p22

Norman Myers reviews One with Nineveh: Politics, Consumption and the Human Future by Paul R. Ehrlich and Anne H. Ehrlich

doi:10.1038/429022a

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Family values p23

H. Charles J. Godfray reviews More than Kin and Less than Kind: the Evolution of Family Conflict by Douglas W. Mock

doi:10.1038/429023a

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Warming to a historical theme p25

Jeremy A. Sabloff reviews The Long Summer: How Climate Changed Civilization by Brian Fagan

doi:10.1038/429025a

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Together forever? p26

Jonathan Cole reviews One of Us: Conjoined Twins and the Future of Normal by Alice Dormurat Dreger

doi:10.1038/429026a

Full Text | PDF (139K)

Essay

Insignificance p27

Dark matter and dark energy: they might be more abundant than the stuff we are made of, but are they any more interesting?

Sean Carroll

doi:10.1038/429027a

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News and Views

Astronomy: Dust-filled doughnuts in space p29

The first images of an extragalactic object to have been captured using infrared interferometry reveal the doughnut-shaped cloud of dust that obscures the heart of a nearby active galaxy.

Julian Krolik

doi:10.1038/429029a

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Regenerative medicine: Self-help for insulin cells p30

Insulin-producing -cells in the adult pancreas were thought to derive from pancreatic stem cells. But it seems that they arise abundantly from -cells themselves, offering a new outlook on regenerative medicine.

Ken Zaret

doi:10.1038/429030a

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Biomechanics: Fast fish p31

Swift-swimming, open-ocean hunters such as mako sharks and tunas need a big engine. Despite their long separation in evolutionary terms, the internal drive systems adopted by these fishes are much the same.

Adam P. Summers

doi:10.1038/429031a

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Earth science: Hot metal p33

The solubility of oxygen in molten iron increases at high temperature. Could this explain why Earth's mantle is poor in iron oxide, whereas the mantle of Mars, which formed under cooler conditions, is not?

Carl B. Agee

doi:10.1038/429033a

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100 and 50 years ago p34

doi:10.1038/429034a

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Human genetics: An inflammatory issue p35

People vary naturally in a protein called caspase-12, and hence in their susceptibility to harmful inflammation. This discovery highlights the balance between the protective and destructive effects of immunity.

Kevin J. Tracey and H. Shaw Warren

doi:10.1038/429035a

Full Text | PDF (131K)

Cell biology: Designer prions p37

Prions are clumps of misshapen proteins that can be passed between cells without the need for genetic intermediaries. The parts of the proteins that account for such infectivity are now being dissected.

Daniel C. Masison

doi:10.1038/429037a

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Materials science: Variations on a golden core p37

Tim Lincoln

doi:10.1038/429037b

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News and views in brief p39

doi:10.1038/429039a

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Brief Communications

Moulting arthropod caught in the act p40

A Cambrian fossil confirms that early arthropods shed their coats just as they do today.

Diego C. García-Bellido and Desmond H. Collins

doi:10.1038/429040a

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Brief Communications Arising

Optical media: Superluminal speed of information?

Günter Nimtz

doi:10.1038/nature02586

First paragraph | Full Text | PDF (52K)

Optical media: Superluminal speed of information? (reply)

Michael D. Stenner, Daniel J. Gauthier and Mark A. Neifeld

doi:10.1038/nature02587

First paragraph | Full Text | PDF (52K)

Article

Adult pancreatic -cells are formed by self-duplication rather than stem-cell differentiation p41

Yuval Dor, Juliana Brown, Olga I. Martinez and Douglas A. Melton

doi:10.1038/nature02520

Abstract | Full Text | PDF (376K)

Letters to Nature

The central dusty torus in the active nucleus of NGC 1068 p47

W. Jaffe, K. Meisenheimer, H. J. A. Röttgering, Ch. Leinert, A. Richichi, O. Chesneau, D. Fraix-Burnet, A. Glazenborg-Kluttig, G.-L. Granato, U. Graser, B. Heijligers, R. Köhler, F. Malbet, G. K. Miley, F. Paresce, J.-W. Pel, G. Perrin, F. Przygodda, M. Schoeller, H. Sol, L. B. F. M. Waters, G. Weigelt, J. Woillez and P. T. de Zeeuw

doi:10.1038/nature02531

First paragraph | Full Text | PDF (222K)

Dislocation-driven surface dynamics on solids p49

S. Kodambaka, S. V. Khare, W. wich, K. Ohmori, I. Petrov and J. E. Greene

doi:10.1038/nature02495

First paragraph | Full Text | PDF (231K)

Polymerization within a molecular-scale stereoregular template p52

Takeshi Serizawa, Ken-ichi Hamada and Mitsuru Akashi

doi:10.1038/nature02525

First paragraph | Full Text | PDF (242K)

Contribution of stratospheric cooling to satellite-inferred tropospheric temperature trends p55

Qiang Fu, Celeste M. Johanson, Stephen G. Warren and Dian J. Seidel

doi:10.1038/nature02524

First paragraph | Full Text | PDF (248K) | Supplementary information

Partitioning of oxygen during core formation on the Earth and Mars p58

David C. Rubie, Christine K. Gessmann and Daniel J. Frost

doi:10.1038/nature02473

First paragraph | Full Text | PDF (265K) | Supplementary information

Convergent evolution in mechanical design of lamnid sharks and tunas p61

Jeanine M. Donley, Chugey A. Sepulveda, Peter Konstantinidis, Sven Gemballa and Robert E. Shadwick

doi:10.1038/nature02435

First paragraph | Full Text | PDF (379K) | Supplementary information

Female mating bias results in conflicting sex-specific offspring fitness p65

Kenneth M. Fedorka and Timothy A. Mousseau

doi:10.1038/nature02492

First paragraph | Full Text | PDF (135K)

Naturalistic experience transforms sensory maps in the adult cortex of caged animals p67

Daniel B. Polley, Eugen Kvaák and Ron D. Frostig

doi:10.1038/nature02469

First paragraph | Full Text | PDF (402K) | Supplementary information

Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin- secretion in vitro p72

Kouichi Ozaki, Katsumi Inoue, Hiroshi Sato, Aritoshi Iida, Yozo Ohnishi, Akihiro Sekine, Hideyuki Sato, Keita Odashiro, Masakiyo Nobuyoshi, Masatsugu Hori, Yusuke Nakamura and Toshihiro Tanaka

doi:10.1038/nature02502

First paragraph | Full Text | PDF (314K) | Supplementary information

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms p75

Maya Saleh, John P. Vaillancourt, Rona K. Graham, Matthew Huyck, Srinivasa M. Srinivasula, Emad S. Alnemri, Martin H. Steinberg, Vikki Nolan, Clinton T. Baldwin, Richard S. Hotchkiss, Timothy G. Buchman, Barbara A. Zehnbauer, Michael R. Hayden, Lindsay A. Farrer, Sophie Roy and Donald W. Nicholson

doi:10.1038/nature02451

First paragraph | Full Text | PDF (340K) | Supplementary information

Nitration of a peptide phytotoxin by bacterial nitric oxide synthase p79

Johan A. Kers, Michael J. Wach, Stuart B. Krasnoff, Joanne Widom, Kimberly D. Cameron, Raghida A. Bukhalid, Donna M. Gibson, Brian R. Crane and Rosemary Loria

doi:10.1038/nature02504

First paragraph | Full Text | PDF (251K) | Supplementary information

Mechanotransduction through growth-factor shedding into the extracellular space p83

Daniel J. Tschumperlin, Guohao Dai, Ivan V. Maly, Tadashi Kikuchi, Lily H. Laiho, Anna K. McVittie, Kathleen J. Haley, Craig M. Lilly, Peter T. C. So, Douglas A. Lauffenburger, Roger D. Kamm and Jeffrey M. Drazen

doi:10.1038/nature02543

First paragraph | Full Text | PDF (273K) | Supplementary information

The ubiquitin ligase COP1 is a critical negative regulator of p53 p86

David Dornan, Ingrid Wertz, Harumi Shimizu, David Arnott, Gretchen D. Frantz, Patrick Dowd, Karen O' Rourke, Hartmut Koeppen and Vishva M. Dixit

doi:10.1038/nature02514

First paragraph | Full Text | PDF (579K) | Supplementary information

Integrating high-throughput and computational data elucidates bacterial networks p92

Markus W. Covert, Eric M. Knight, Jennifer L. Reed, Markus J. Herrgard and Bernhard O. Palsson

doi:10.1038/nature02456

First paragraph | Full Text | PDF (885K) | Supplementary information

Technology Features

Protein arrays: Proteomics in multiplex p101

Protein arrays and protein assays in parallel are enabling researchers to look at protein interactions and activity on a large scale, as Lisa Melton finds out.

Lisa Melton

doi:10.1038/429101a

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Do-it-yourself arrays p101

doi:10.1038/429101b

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A natural affinity p103

doi:10.1038/429103a

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Family business p105

doi:10.1038/429105a

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Breaking down the problem p107

doi:10.1038/429107a

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Table of suppliers p109

doi:10.1038/429109a

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Naturejobs

Swatting flies p111

Paul Smaglik

doi:10.1038/nj6987-111a

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Graduate Journal: Through the looking glass p112

Amber Jenkins

doi:10.1038/nj6987-112a

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Nuts & Bolts p112

Deb Koen

doi:10.1038/nj6987-112b

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Movers p112

doi:10.1038/nj6987-112c

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