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Cell biology

Designer prions

Prions are clumps of misshapen proteins that can be passed between cells without the need for genetic intermediaries. The parts of the proteins that account for such infectivity are now being dissected.

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Figure 1: The modular properties of prion domains.

References

  1. Osherovich, L. Z., Cox, B. S., Tuite, M. F. & Weissman, J. S. PLoS Biol. 2, 0442–0451 (2004).

    Article  CAS  Google Scholar 

  2. Chernoff, Y. O., Lindquist, S. L., Ono, B., Inge-Vechtomov, S. G. & Liebman, S. W. Science 268, 880–884 (1995).

    Article  ADS  CAS  Google Scholar 

  3. Paushkin, S. V., Kushnirov, V. V., Smirnov, V. N. & Ter-Avanesyan, M. D. EMBO J. 15, 3127–3134 (1996).

    Article  CAS  Google Scholar 

  4. Santoso, A., Chien, P., Osherovich, L. Z. & Weissman, J. S. Cell 100, 277–288 (2000).

    Article  CAS  Google Scholar 

  5. Cummings, C. J. & Zoghbi, H. Y. Annu. Rev. Genomics Hum. Genet. 1, 281–328 (2000).

    Article  CAS  Google Scholar 

  6. Crist, C. G., Nakayashiki, T., Kurahashi, H. & Nakamura, Y. Genes Cells 8, 603–618 (2003).

    Article  CAS  Google Scholar 

  7. Weissmann, C. & Flechsig, E. Br. Med. Bull. 66, 43–60 (2003).

    Article  CAS  Google Scholar 

  8. Parham, S. N., Resende, C. G. & Tuite, M. F. EMBO J. 20, 2111–2119 (2001).

    Article  CAS  Google Scholar 

  9. Liu, J. J. & Lindquist, S. Nature 400, 573–576 (1999).

    Article  ADS  CAS  Google Scholar 

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Masison, D. Designer prions. Nature 429, 37–38 (2004). https://doi.org/10.1038/429037a

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