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Nature 428, 809-811 (22 April 2004) | doi:10.1038/428809a

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Genomic imprinting:  Mice without a father

David A. F. Loebel1 & Patrick P. L. Tam1

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In mammals, genomes from both parents are generally needed to make viable offspring. But changing the expression of 'imprinted' genes can render the father's contribution dispensable.

Sexual reproduction in animals ensures that each individual normally inherits one set of genes from each parent. But viable offspring that have only maternal genes — none from the father — can be produced through parthenogenetic reproduction in plants and most groups of animals.

  1. David A. F. Loebel and Patrick P. L. Tam are in the Embryology Unit, Children's Medical Research Institute, University of Sydney, Wentworthville, New South Wales 2145, Australia.
    e-mails: Email: dloebel@cmri.usyd.edu.au
    ptam@cmri.usyd.edu.au

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