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Nature 428, 703-704 (15 April 2004) | doi:10.1038/428703a

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Evolutionary biology: Lost and found

Neil H. Shubin1 & Randall D. Dahn1

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Can we ever hope to pin down the genetic changes that underlie the big steps in evolution? Possibly so, if a study of the variation in the pelvic fins of sticklebacks is anything to go by.

Darwin's lament1 that "Our ignorance of the laws of variation is profound" has described one of the persistent problems in evolutionary biology for the past 145 years. How does genetic variation — the raw material of evolution — arise within populations, and how does it evolve to make species anatomically and behaviourally distinct?

  1. Neil H. Shubin and Randall D. Dahn are in the Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637, USA.
    e-mail: Email: nshubin@uchicago.edu

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