Editorials

Playing a dangerous game p451

The current US administration is edging towards a policy of developing new types of nuclear weapons. In today's uncertain world, the last thing we need is a renewed arms race among the world's nuclear powers.

doi:10.1038/428451a

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A fair deal for all p451

Scientists in poorer countries have to pay over the odds for equipment and reagents. They deserve a helping hand.

doi:10.1038/428451b

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News

High prices of supplies drain cash from poorer nations' labs p453

Eva Schillinger

doi:10.1038/428453a

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Bioterror tester kits trouble federal agencies p454

Erika Check

doi:10.1038/428454a

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Rebelling scientists welcome left's landslide in France p454

Declan Butler

doi:10.1038/428454b

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Democrats slam Bush plan for fresh nuclear weapons p455

Geoff Brumfiel

doi:10.1038/428455a

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Australia considers revised scheme for young researchers p455

Carina Dennis

doi:10.1038/428455b

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Founder bows out as genomic firm slashes workforce p456

Meredith Wadman

doi:10.1038/428456a

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Biologists get ball rolling to aid neglected invertebrates p456

Helen Pearson

doi:10.1038/428456b

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Defence work sheds light on hospital bacteria p457

Laura Nelson

doi:10.1038/428457a

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Letters to the Editor deliver fitting April message p457

Alison Abbott

doi:10.1038/428457b

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News in brief p458

doi:10.1038/428458a

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News Features

Information technology:  In the know p462

In big groups and companies, it's hard to track who knows what. So how can scientists share information and prevent work being duplicated? Philip Ball investigates one solution: knowledge-management software.

doi:10.1038/428462a

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Laboratory animals:  The Renaissance rat p464

Thanks to the availability of its genome sequence, and the promise of new genetically engineered strains, the rat is restoring its reputation as researchers' favourite lab animal. Alison Abbott hails a remarkable rodent.

doi:10.1038/428464a

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Correspondence

Ancient frog could spearhead conservation efforts p467

Newly discovered, this unique creature is already under threat from dam projects.

Ramesh K. Aggarwal

doi:10.1038/428467a

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Diversity project takes time but reaps rewards p467

Luigi Luca Cavalli-Sforza

doi:10.1038/428467b

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Small change p467

Stephen E. Moss

doi:10.1038/428467c

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Irrelevance, buzzwords, coffee: it's the virtual PI p467

Several non-robot scientists

doi:10.1038/428467d

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Books and Arts

Power to the people p469

An analysis of the problems caused by an increasing energy demand.

Michael Grubb reviews Energy at the Crossroads: Global Perspectives and Uncertainties by Vaclav Smil

doi:10.1038/428469a

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Autistic genius? p470

Allan Snyder reviews Autism and Creativity: Is There a Link between Autism in Men and Exceptional Ability? by Michael Fitzgerald and Autism: Mind and Brain

doi:10.1038/428470a

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Science in culture p471

The German Hygiene Museum in Dresden is reopening its doors.

Alison Abbott

doi:10.1038/428471a

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Essay

Turning down, but not off p473

Neuroprotection requires a paradigm shift in drug development.

Stuart A. Lipton

doi:10.1038/428473a

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News and Views

Genome sequencing:  Three's company p475

Publication of the rat genome sequence will not only advance physiological studies in this paragon of laboratory animals, but also greatly enhance the power of comparative research into mammalian genomes.

Kerstin Lindblad-Toh

doi:10.1038/428475a

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Earth science:  Inside history in depth p476

The history of how Earth's interior evolved, and how it accounts for many aspects of our planet's behaviour, remains largely unwritten. Taking water into account could well help to explain a great deal more.

David Stevenson

doi:10.1038/428476a

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Entomology:  Butterflies at that awkward age p477

Beautifully preserved specimens of butterflies from the Caribbean, caught maybe in the act of egg-laying some 20 million years ago, provide welcome grist to the mill of debate about butterfly history.

Dick Vane-Wright

doi:10.1038/428477a

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Evolutionary biology:  Ferns reawakened p480

The principle of the evolutionary cul-de-sac is commonly invoked to explain the apparent lingering existence of once-diverse groups of organisms. Maybe that principle itself has had its day.

Torsten Eriksson

doi:10.1038/428480a

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Nanoscale physics:  Big moment for nanotubes p481

May Chiao

doi:10.1038/428481a

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Obituary:  J. Beverley Oke (1928–2004) p483

Wallace Sargent

doi:10.1038/428483a

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News and views in brief p484

doi:10.1038/428484a

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Brief Communications

Gene regulation:  Ancient microRNA target sequences in plants p485

A gene-regulation mechanism in plants predates the emergence of flowering species.

Sandra K. Floyd and John L. Bowman

doi:10.1038/428485a

First paragraph | Full Text | PDF (243K) | Supplementary information

Medical genetics:  A marker for Stevens–Johnson syndrome p486

Wen-Hung Chung, Shuen-Iu Hung, Hong-Shang Hong, Mo-Song Hsih, Li-Cheng Yang, Hsin-Chun Ho, Jer-Yuarn Wu and Yuan-Tsong Chen

doi:10.1038/428486a

First paragraph | Full Text | PDF (103K) | Supplementary information

Brief Communications Arising

Tumour suppression:  Disruption of HAUSP gene stabilizes p53

Jordan M. Cummins, Carlo Rago, Manu Kohli, Kenneth W. Kinzler, Christoph Lengauer and Bert Vogelstein

doi:10.1038/nature02501

First paragraph | Full Text | PDF (145K)

Review

Designing materials for biology and medicine p487

Robert Langer and David A. Tirrell

doi:10.1038/nature02388

Abstract | Full Text | PDF (267K) | Supplementary information

Articles

Genome sequence of the Brown Norway rat yields insights into mammalian evolution p493

Rat Genome Sequencing Project Consortium

doi:10.1038/nature02426

Abstract | Full Text | PDF (1,215K) | Supplementary information

See also: News and Views by Lindblad-Toh

The DNA sequence and analysis of human chromosome 13 p522

A. Dunham, L. H. Matthews, J. Burton, J. L. Ashurst, K. L. Howe, K. J. Ashcroft, D. M. Beare, D. C. Burford, S. E. Hunt, S. Griffiths-Jones, M. C. Jones, S. J. Keenan, K. Oliver, C. E. Scott, R. Ainscough, J. P. Almeida, K. D. Ambrose, D. T. Andrews, R. I. S. Ashwell, A. K. Babbage, C. L. Bagguley, J. Bailey, R. Bannerjee, K. F. Barlow, K. Bates, H. Beasley, C. P. Bird, S. Bray-Allen, A. J. Brown, J. Y. Brown, W. Burrill, C. Carder, N. P. Carter, J. C. Chapman, M. E. Clamp, S. Y. Clark, G. Clarke, C. M. Clee, S. C. M. Clegg, V. Cobley, J. E. Collins, N. Corby, G. J. Coville, P. Deloukas, P. Dhami, I. Dunham, M. Dunn, M. E. Earthrowl, A. G. Ellington, L. Faulkner, A. G. Frankish, J. Frankland, L. French, P. Garner, J. Garnett, J. G. R. Gilbert, C. J. Gilson, J. Ghori, D. V. Grafham, S. M. Gribble, C. Griffiths, R. E. Hall, S. Hammond, J. L. Harley, E. A. Hart, P. D. Heath, P. J. Howden, E. J. Huckle, P. J. Hunt, A. R. Hunt, C. Johnson, D. Johnson, M. Kay, A. M. Kimberley, A. King, G. K. Laird, C. J. Langford, S. Lawlor, D. A. Leongamornlert, D. M. Lloyd, C. Lloyd, J. E. Loveland, J. Lovell, S. Martin, M. Mashreghi-Mohammadi, S. J. McLaren, A. McMurray, S. Milne, M. J. F. Moore, T. Nickerson, S. A. Palmer, A. V. Pearce, A. I. Peck, S. Pelan, B. Phillimore, K. M. Porter, C. M. Rice, S. Searle, H. K. Sehra, R. Shownkeen, C. D. Skuce, M. Smith, C. A. Steward, N. Sycamore, J. Tester, D. W. Thomas, A. Tracey, A. Tromans, B. Tubby, M. Wall, J. M. Wallis, A. P. West, S. L. Whitehead, D. L. Willey, L. Wilming, P. W. Wray, M. W. Wright, L. Young, A. Coulson, R. Durbin, T. Hubbard, J. E. Sulston, S. Beck, D. R. Bentley, J. Rogers and M. T. Ross

doi:10.1038/nature02379

Abstract | Full Text | PDF (662K) | Supplementary information

The DNA sequence and biology of human chromosome 19 p529

Jane Grimwood, Laurie A. Gordon, Anne Olsen, Astrid Terry, Jeremy Schmutz, Jane Lamerdin, Uffe Hellsten, David Goodstein, Olivier Couronne, Mary Tran-Gyamfi, Andrea Aerts, Michael Altherr, Linda Ashworth, Eva Bajorek, Stacey Black, Elbert Branscomb, Sean Caenepeel, Anthony Carrano, Chenier Caoile, Yee Man Chan, Mari Christensen, Catherine A. Cleland, Alex Copeland, Eileen Dalin, Paramvir Dehal, Mirian Denys, John C. Detter, Julio Escobar, Dave Flowers, Dea Fotopulos, Carmen Garcia, Anca M. Georgescu, Tijana Glavina, Maria Gomez, Eidelyn Gonzales, Matthew Groza, Nancy Hammon, Trevor Hawkins, Lauren Haydu, Isaac Ho, Wayne Huang, Sanjay Israni, Jamie Jett, Kristen Kadner, Heather Kimball, Arthur Kobayashi, Vladimer Larionov, Sun-Hee Leem, Frederick Lopez, Yunian Lou, Steve Lowry, Stephanie Malfatti, Diego Martinez, Paula McCready, Catherine Medina, Jenna Morgan, Kathryn Nelson, Matt Nolan, Ivan Ovcharenko, Sam Pitluck, Martin Pollard, Anthony P. Popkie, Paul Predki, Glenda Quan, Lucia Ramirez, Sam Rash, James Retterer, Alex Rodriguez, Stephanine Rogers, Asaf Salamov, Angelica Salazar, Xinwei She, Doug Smith, Tom Slezak, Victor Solovyev, Nina Thayer, Hope Tice, Ming Tsai, Anna Ustaszewska, Nu Vo, Mark Wagner, Jeremy Wheeler, Kevin Wu, Gary Xie, Joan Yang, Inna Dubchak, Terrence S. Furey, Pieter DeJong, Mark Dickson, David Gordon, Evan E. Eichler, Len A. Pennacchio, Paul Richardson, Lisa Stubbs, Daniel S. Rokhsar, Richard M. Myers, Edward M. Rubin and Susan M. Lucas

doi:10.1038/nature02399

Abstract | Full Text | PDF (317K) | Supplementary information

Letters to Nature

Determination of electron orbital magnetic moments in carbon nanotubes p536

E. D. Minot, Yuval Yaish, Vera Sazonova and Paul L. McEuen

doi:10.1038/nature02425

First paragraph | Full Text | PDF (393K)

Current-induced domain-wall switching in a ferromagnetic semiconductor structure p539

M. Yamanouchi, D. Chiba, F. Matsukura and H. Ohno

doi:10.1038/nature02441

First paragraph | Full Text | PDF (451K)

Superconductivity in diamond p542

E. A. Ekimov, V. A. Sidorov, E. D. Bauer, N. N. Mel'nik, N. J. Curro, J. D. Thompson and S. M. Stishov

doi:10.1038/nature02449

First paragraph | Full Text | PDF (278K)

Intermediate-depth earthquake faulting by dehydration embrittlement with negative volume change p545

Haemyeong Jung, Harry W. Green II and Larissa F. Dobrzhinetskaya

doi:10.1038/nature02412

First paragraph | Full Text | PDF (409K)

The decline and fate of an iron-induced subarctic phytoplankton bloom p549

Philip W. Boyd, Cliff S. Law, C.S. Wong, Yukihiro Nojiri, Atsushi Tsuda, Maurice Levasseur, Shigenobu Takeda, Richard Rivkin, Paul J. Harrison, Robert Strzepek, Jim Gower, R. Mike McKay, Edward Abraham, Mike Arychuk, Janet Barwell-Clarke, William Crawford, David Crawford, Michelle Hale, Koh Harada, Keith Johnson, Hiroshi Kiyosawa, Isao Kudo, Adrian Marchetti, William Miller, Joe Needoba, Jun Nishioka, Hiroshi Ogawa, John Page, Marie Robert, Hiroaki Saito, Akash Sastri, Nelson Sherry, Tim Soutar, Nes Sutherland, Yosuke Taira, Frank Whitney, Shau-King Emmy Wong and Takeshi Yoshimura

doi:10.1038/nature02437

First paragraph | Full Text | PDF (231K) | Supplementary information

Ferns diversified in the shadow of angiosperms p553

Harald Schneider, Eric Schuettpelz, Kathleen M. Pryer, Raymond Cranfill, Susana Magallón and Richard Lupia

doi:10.1038/nature02361

First paragraph | Full Text | PDF (609K) | Supplementary information

See also: News and Views by Eriksson

Adaptation to natural facial categories p557

Michael A. Webster, Daniel Kaping, Yoko Mizokami and Paul Duhamel

doi:10.1038/nature02420

First paragraph | Full Text | PDF (386K)

A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice p561

Zhi-yong Yang, Wing-pui Kong, Yue Huang, Anjeanette Roberts, Brian R. Murphy, Kanta Subbarao and Gary J. Nabel

doi:10.1038/nature02463

First paragraph | Full Text | PDF (219K) | Supplementary information

Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries p564

Toshie Kai and Allan Spradling

doi:10.1038/nature02436

First paragraph | Full Text | PDF (536K) | Supplementary information

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus p569

Yasuhiko Minokoshi, Thierry Alquier, Noboru Furukawa, Young-Bum Kim, Anna Lee, Bingzhong Xue, James Mu, Fabienne Foufelle, Pascal Ferré, Morris J. Birnbaum, Bettina J. Stuck and Barbara B. Kahn

doi:10.1038/nature02440

First paragraph | Full Text | PDF (477K) | Supplementary information

From molecular noise to behavioural variability in a single bacterium p574

Ekaterina Korobkova, Thierry Emonet, Jose M. G. Vilar, Thomas S. Shimizu and Philippe Cluzel

doi:10.1038/nature02404

First paragraph | Full Text | PDF (528K) | Supplementary information

The myosin motor in muscle generates a smaller and slower working stroke at higher load p578

Massimo Reconditi, Marco Linari, Leonardo Lucii, Alex Stewart, Yin-Biao Sun, Peter Boesecke, Theyencheri Narayanan, Robert F. Fischetti, Tom Irving, Gabriella Piazzesi, Malcolm Irving and Vincenzo Lombardi

doi:10.1038/nature02380

First paragraph | Full Text | PDF (280K) | Supplementary information

Naturejobs

Exploring careers p583

Paul Smaglik

doi:10.1038/nj6982-583a

Full Text | PDF (129K)

Changing of the guard p584

Opportunities in bioinformatics once abounded for the self-taught and industrially minded, but employers are now turning towards the formally trained and academics. Myrna Watanabe reports.

Myrna Watanabe

doi:10.1038/nj6982-584a

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Graduate Journal:  Undertaking undergraduates p586

Sidney Omelon

doi:10.1038/nj6982-586a

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Nuts & Bolts p586

Deb Koen

doi:10.1038/nj6982-586b

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Movers p586

doi:10.1038/nj6982-586c

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