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From the following article:

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Yasuhiko Minokoshi, Thierry Alquier, Noboru Furukawa, Young-Bum Kim, Anna Lee, Bingzhong Xue, James Mu, Fabienne Foufelle, Pascal Ferré, Morris J. Birnbaum, Bettina J. Stuck and Barbara B. Kahn

Nature 428, 569-574(1 April 2004)

doi:10.1038/nature02440

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Leptin, insulin, MT-II and glucose decrease alpha2AMPK activity in the hypothalamus.

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Figure 2

Modulation of AMPK activity in the hypothalamus is sufficient to alter body weight and food intake.

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Figure 3

Effects of leptin are impaired with CA-AMPK in the hypothalamus.

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Figure 4

Proposed model for role of AMPK in anorexigenic signalling in the hypothalamus.

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