Editorial

White heat — at last p351

Britain's political leadership, for the first time in decades, is well placed to take a reasoned, strategic approach to the long-term development of science and innovation. But watch out for resurgent bureaucracy.

doi:10.1038/428351a

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News

NASA seeks robotic rescuers to give Hubble extra lease of life p353

Tony Reichhardt

doi:10.1038/428353a

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Link from hygiene to allergies gains support p354

Erika Check

doi:10.1038/428354a

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Biology hogs the science budget, senator complains p354

Erika Check

doi:10.1038/428354b

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Partners fail to find common ground for fusion project p355

Declan Butler

doi:10.1038/428355a

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Ice machine sheds light on climate history written in dust p355

Jim Giles

doi:10.1038/428355b

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Societies take united stand on journal access p356

Jim Giles

doi:10.1038/428356a

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US Army backs Swedish cell study p356

Alison Abbott

doi:10.1038/428356b

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Japan shakes up council to offer scientists political clout p357

David Cyranoski

doi:10.1038/428357a

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Sellafield seeks solid foundation for cleaner wastewater p357

Laura Nelson

doi:10.1038/428357b

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News in brief p358

doi:10.1038/428358a

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News Features

Rice cultivation:  Feast or famine? p360

Proponents call it a miracle. Detractors call it smoke and mirrors. Will the System of Rice Intensification feed the hungry third world or needlessly divert farmers from tried and true techniques? Christopher Surridge investigates.

doi:10.1038/428360a

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Neuroscience:  The sweet smell of success p362

Smell is arguably the most evocative and mysterious of our senses. But thanks to advances in our understanding of the cells that detect odour, its secrets should now start to be revealed. Carina Dennis sniffs around.

doi:10.1038/428362a

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Correspondence

New law does little to ease research pain in Spain p365

Validation of foreign degrees is still mired in expensive, time-consuming bureaucracy.

Mark van Raaij

doi:10.1038/428365a

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Spain: politicians need to challenge the status quo p365

Miguel Ortiz Lombardía

doi:10.1038/428365b

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Fusion: Bush agrees it's time to end the impasse p365

Burton Richter

doi:10.1038/428365c

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Fusion: choose Japan for international balance p365

Michael E. Mauel

doi:10.1038/428365d

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Books and Arts

The physics of crowds p367

Once social scientists inspired physicists. Now the reverse is true.

Steven Strogatz reviews Critical Mass: How One Thing Leads to Another by Philip Ball

doi:10.1038/428367a

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Chemistry between man and insect p368

Jeremy N. McNeil reviews For Love of Insects by Thomas Eisner

doi:10.1038/428368a

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A sprinkling of stardust p369

John J. Cowan reviews Stellar Alchemy: The Celestial Origin of Atoms by Michel Cassé

doi:10.1038/428369a

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New in paperback p369

doi:10.1038/428369b

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Science in culture p370

The idea that the golden section had a special place in Renaissance painting makes for fine fiction but rotten history.

Martin Kemp reviews

doi:10.1038/428370a

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Essay

Cell bodies in a cage p371

A new 'cell theory' is needed to explain complex intercellular connections.

Frantiek Baluka, Dieter Volkmann and Peter W. Barlow

doi:10.1038/428371a

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News and Views

Human genetics:  Muscling in on hominid evolution p373

A molecular difference in the jaw muscles of human and non-human primates has tantalizing echoes in the fossil record. Was this divergence a central event in the evolution of the skull of modern hominids?

Pete Currie

doi:10.1038/428373a

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Crystallization:  How come you look so good? p374

Crystallized brown sugar is quite miraculous: it takes just a few 'seeds' in the crystallization process to trigger the formation of many times more crystals. Now we are starting to understand why.

Roger J. Davey

doi:10.1038/428374a

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RNA interference:  Human genes hit the big screen p375

Genetic screens are powerful tools for identifying the genes involved in specific biological processes. At last, RNA interference makes large-scale screens possible in mammalian cells.

Andrew Fraser

doi:10.1038/428375a

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100 and 50 years ago p377

doi:10.1038/428377a

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Learning theory:  Past performance and future results p378

Learning from experience is hard, and predicting how well what we have learned will serve us in the future is even harder. The most useful lessons turn out to be those that are insensitive to small changes in our experience.

Carlo Tomasi

doi:10.1038/428378a

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Earth science:  Putting the squeeze on oxidation p379

The results of experiments conducted under the extreme temperature and pressure conditions of Earth's lower mantle suggest that, at these depths, low oxygen content is no barrier to iron oxidation.

Michael J. Walter

doi:10.1038/428379a

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Medicine:  Profile of a tumour p379

Molecular profiling — the comprehensive analysis of genes, RNAs and proteins — is having a radical effect on our understanding of cancer. The next step is to convert these findings into better diagnosis and treatment.

Olli Kallioniemi

doi:10.1038/428379b

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Planetary science:  Stardust's comet memories p381

Alison Wright

doi:10.1038/428381a

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Signal processing:  Neural coding by correlation? p382

Noise limits the efficiency of information transfer. But correlations of the intervals between signal pulses can reduce low-frequency noise and thereby increase the transfer of information.

Arun V. Holden

doi:10.1038/428382a

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news and views in brief p383

doi:10.1038/428384a

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Brief Communications

Equine welfare:  Risk of horses falling in the Grand National p385

Analysis of past tumbles in this gruelling steeplechase points to ways of making it safer.

Christopher Proudman, Gina Pinchbeck, Peter Clegg and Nigel French

doi:10.1038/428385a

First paragraph | Full Text | PDF (247K) | Supplementary information

Microperiodic structures:  Direct writing of three-dimensional webs p386

Gregory M. Gratson, Mingjie Xu and Jennifer A. Lewis

doi:10.1038/428386a

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Brief Communications Arising

Cosmology:  Synchrotron radiation and quantum gravity

John Ellis, N. E. Mavromatos, D. V. Nanopoulos and A. S. Sakharov

doi:10.1038/nature02481

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Articles

Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo p387

Masamichi Yamamoto, Yukio Saijoh, Aitana Perea-Gomez, William Shawlot, Richard R. Behringer, Siew-Lan Ang, Hiroshi Hamada and Chikara Meno

doi:10.1038/nature02418

Abstract | Full Text | PDF (391K) | Supplementary information

Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons p393

Jinsong Li, Tomohiro Ishii, Paul Feinstein and Peter Mombaerts

doi:10.1038/nature02433

Abstract | Full Text | PDF (482K)

Letters to Nature

Retrograde spins of near-Earth asteroids from the Yarkovsky effect p400

A. La Spina, P. Paolicchi, A. Kryszczyska and P. Pravec

doi:10.1038/nature02411

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Strain-induced metal–insulator phase coexistence in perovskite manganites p401

K. H. Ahn, T. Lookman and A. R. Bishop

doi:10.1038/nature02364

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Onset of heterogeneous crystal nucleation in colloidal suspensions p404

A. Cacciuto, S. Auer and D. Frenkel

doi:10.1038/nature02397

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See also: News and Views by Davey

Mass and volume contributions to twentieth-century global sea level rise p406

Laury Miller and Bruce C. Douglas

doi:10.1038/nature02309

First paragraph | Full Text | PDF (294K)

Experimental evidence for the existence of iron-rich metal in the Earth's lower mantle p409

Daniel J. Frost, Christian Liebske, Falko Langenhorst, Catherine A. McCammon, Reidar G. Trønnes and David C. Rubie

doi:10.1038/nature02413

First paragraph | Full Text | PDF (225K)

See also: News and Views by Walter

Antibiotic-mediated antagonism leads to a bacterial game of rock–paper–scissors in vivo p412

Benjamin C. Kirkup and Margaret A. Riley

doi:10.1038/nature02429

First paragraph | Full Text | PDF (364K)

Myosin gene mutation correlates with anatomical changes in the human lineage p415

Hansell H. Stedman, Benjamin W. Kozyak, Anthony Nelson, Danielle M. Thesier, Leonard T. Su, David W. Low, Charles R. Bridges, Joseph B. Shrager, Nancy Minugh-Purvis and Marilyn A. Mitchell

doi:10.1038/nature02358

First paragraph | Full Text | PDF (487K) | Supplementary information

See also: News and Views by Currie

General conditions for predictivity in learning theory p419

Tomaso Poggio, Ryan Rifkin, Sayan Mukherjee and Partha Niyogi

doi:10.1038/nature02341

First paragraph | Full Text | PDF (148K)

See also:

First paragraph | Full Text | PDF (814K) | Supplementary information

A resource for large-scale RNA-interference-based screens in mammals p427

Patrick J. Paddison, Jose M. Silva, Douglas S. Conklin, Mike Schlabach, Mamie Li, Shola Aruleba, Vivekanand Balija, Andy O'Shaughnessy, Lidia Gnoj, Kim Scobie, Kenneth Chang, Thomas Westbrook, Michele Cleary, Ravi Sachidanandam, W. Richard McCombie, Stephen J. Elledge and Gregory J. Hannon

doi:10.1038/nature02370

First paragraph | Full Text | PDF (367K) | Supplementary information

See also: News and Views by Fraser

A large-scale RNAi screen in human cells identifies new components of the p53 pathway p431

Katrien Berns, E. Marielle Hijmans, Jasper Mullenders, Thijn R. Brummelkamp, Arno Velds, Mike Heimerikx, Ron M. Kerkhoven, Mandy Madiredjo, Wouter Nijkamp, Britta Weigelt, Reuven Agami, Wei Ge, Guy Cavet, Peter S. Linsley, Roderick L. Beijersbergen and René Bernards

doi:10.1038/nature02371

First paragraph | Full Text | PDF (656K) | Supplementary information

See also: News and Views by Fraser

Functional interactions between receptors in bacterial chemotaxis p437

Victor Sourjik and Howard C. Berg

doi:10.1038/nature02406

First paragraph | Full Text | PDF (314K) | Supplementary information

Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria p441

Omita A. Trivedi, Pooja Arora, Vijayalakshmi Sridharan, Rashmi Tickoo, Debasisa Mohanty and Rajesh S. Gokhale

doi:10.1038/nature02384

First paragraph | Full Text | PDF (559K) | Supplementary information

Corrigendum: Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila p445

Cyrille de Joussineau, Jonathan Soulé, Marianne Martin, Christelle Anguille, Philippe Montcourrier and Daniel Alexandre

doi:10.1038/nature02401

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Erratum: Folding proteins in fatal ways p445

Dennis J. Selkoe

doi:10.1038/nature02477

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Naturejobs

The fame game p447

Paul Smaglik

doi:10.1038/nj6981-447a

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Renaissance in Spain p448

Quirin Schiermeier

doi:10.1038/nj6981-448a

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Graduate Journal:  Paris, here I come... p450

Tshaka Cunningham

doi:10.1038/nj6981-450a

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Recruiters & Industry p450

Michael Jackson

doi:10.1038/nj6981-450b

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Movers p450

doi:10.1038/nj6981-450c

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