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News and Views
Nature 428, 375-378 (25 March 2004) | doi:10.1038/428375a
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Sr. Scientific Manager / Chief Scientific Manager - Discovery Bioanalytical Research and Biotransformation
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RNA interference: Human genes hit the big screen
Andrew Fraser1
Abstract
Genetic screens are powerful tools for identifying the genes involved in specific biological processes. At last, RNA interference makes large-scale screens possible in mammalian cells.
One of the most intuitive ways to learn how a complicated machine works is to take it apart piece by piece — a directed 'learning by breaking'. For biologists, teasing apart the machinery underlying the form and function of an organism can be done, most simply, by removing genes one at a time and looking at the effect.
- Andrew Fraser is at the Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Email: agf@sanger.ac.uk
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