Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 428, 375-378 (25 March 2004) | doi:10.1038/428375a
Open Innovation Challenges
-
Optimizing Sub-cellular Localization Tags
The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression....
-
Methods of Modeling Adaptation in Populations
The analysis of adaptation with a population is a frequently encountered computational modeling scen...
- More Challenges
- Powered by:
nature jobs
Sr. Scientific Manager / Chief Scientific Manager - Discovery Bioanalytical Research and Biotransformation
- Syngene International
- Bangalore, Karnataka 560099 India
Postdoctoral Positions
- Johns Hopkins University
- Baltimore, Maryland, USA
RNA interference: Human genes hit the big screen
Andrew Fraser1
Abstract
Genetic screens are powerful tools for identifying the genes involved in specific biological processes. At last, RNA interference makes large-scale screens possible in mammalian cells.
One of the most intuitive ways to learn how a complicated machine works is to take it apart piece by piece — a directed 'learning by breaking'. For biologists, teasing apart the machinery underlying the form and function of an organism can be done, most simply, by removing genes one at a time and looking at the effect.
- Andrew Fraser is at the Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Email: agf@sanger.ac.uk
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
5,000 RNAi experiments on a chipNature Methods News and Views (01 Nov 2004)
Medicine Silencing viruses with RNANature News and Views (25 Jul 2002)
See all 3 matches for News And ViewsRESEARCH
Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesisNature Methods Article (01 Dec 2004)
Restriction enzyme?generated siRNA (REGS) vectors and librariesNature Genetics Technical Report (01 Feb 2004)
See all 36 matches for Research