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Nature 428, 267-269 (18 March 2004) | doi:10.1038/428267a

Open Innovation Challenges

Cancer:  Survival pathways meet their end

Frank McCormick1

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Conventional chemotherapeutic approaches to treating tumours can be hit-and-miss. One way to ensure successful treatment may be to go for the jugular of cancer-cell survival signalling as well.

Chemotherapy uses powerful drugs designed to induce cancer cells to commit suicide. So why don't all tumours succumb to these drugs?

  1. Frank McCormick is at the Comprehensive Cancer Center, University of California, San Francisco, Box 0128, 2340 Sutter Street, San Francisco, California 94143, USA.
    e-mail: Email: mccormick@cc.ucsf.edu

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