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Nature 428, 28-29 (4 March 2004) | doi:10.1038/428028a
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Cell biology: A cellular choreographer
W. James Nelson1
Abstract
Specialized cells that form barriers such as those of the intestine adopt a distinct asymmetry. One particular protein may be a prime mover in bringing about such cellular organization.
The intestine is a hollow tube lined by finger-like projections (villi) which, in turn, are covered by a sheet of highly organized cells. As in other exposed surfaces such as the skin, these specialized epithelial cells are born at the bottom of the layer and move up to replace cells that are constantly being sloughed off the top.
- W. James Nelson is in the Department of Molecular and Cellular Physiology, Beckman Center, B121, 279 Campus Drive, Stanford University School of Medicine, Stanford, California 94305-5435, USA.
e-mail: Email: wjnelson@stanford.edu
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